Pulmonary large cell carcinomas with neuroendocrine features are high-grade neuroendocrine tumors Akira Iyoda, MD, Kenzo Hiroshima, MD, Masayuki Baba,

Slides:

Advertisements

Similar presentations

Part 10B: Histopathology of small cell lung cancer Prepared By Bronchoscopy International Contact us at BRONCHATLAS ©

Advertisements

Neoplasia p.1 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Neoplasia Definitions Nomenclature Characteristics of benign and malignant neoplasms Epidemiology.

First author: Roman Adina Co-author: Andone Sebastian

KCP 750 경북대학교병원 병리학교실 R3 김미선. History 63 세 여자환자 8 년전에 왼쪽 골반 통증으로 내원 -> 흉부전산화단층 촬영 : 양측 폐에 10 개정 도의 작은 결절 작년에 오른쪽 어깨와 등의 통증으로 내원 -> 흉부전산화단층 촬영에서 양측 폐의.

Neuroendocrine and biologic features of primary tumors and tissue in pulmonary large cell carcinomas Alexandre M Ab' Saber, MD, Ledo Mazzei Massoni Neto,

Discriminant Model for Cytologic Distinction of Large Cell Neuroendocrine Carcinoma from Small Cell Carcinoma of the Lung Rira Hoshi, CT, Noriyuki Furuta,

JOSEPH T. SOBOTA, M.D., RICHARD J. REED, M.D. Diseases of the Chest

Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic.

An improved orthotopic xenotransplant procedure for human lung cancer in SCID bg mice Arnd S Boehle, MD, Peter Dohrmann, PhD, Ivo Leuschner, MD, Holger.

High-Grade Neuroendocrine Carcinoma with Bronchial Intraepithelial Tumor Spread Hideaki Kojima, MD, Reiko Watanabe, MD, PhD, Mitsuhiro Isaka, MD, PhD,

The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study.

Didier Lardinois, MD, Renate Rechsteiner, MD, R

Large cell neuroendocrine carcinoma of the lung: a 10-year clinicopathologic retrospective study Massimiliano Paci, MD, Alberto Cavazza, MD, Valerio.

Part 10C: Histopathology of small cell lung cancer

Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.

Prediction of Prognosis and Surgical Indications for Pulmonary Metastasectomy From Colorectal Cancer Toshihiko Iizasa, MD, Makoto Suzuki, MD, Shigetoshi.

Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.

Molecular Markers Help Characterize Neuroendocrine Lung Tumors

Fast-Growing Large Cell Neuroendocrine Carcinoma of Mediastinum

Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung Kenzo Hiroshima, MD, Akira Iyoda, MD, Kiyoshi Shibuya, MD, Tetsuya.

Primary synovial sarcoma of the left heart

Anja C. Roden, MD, Patricia T. Greipp, DO, Darlene L. Knutson, Sara M

Tumor Angiogenesis as a Prognostic Marker in Operable Non–Small Cell Lung Cancer Katsuhiko Matsuyama, Yukio Chiba, Masato Sasaki, Hirokazu Tanaka, Ryusuke.

Large Cell Neuroendocrine Carcinoma of the Mediastinum with α-Fetoprotein Production Ken Takezawa, MD, Isamu Okamoto, MD, PhD, Junya Fukuoka, MD, PhD,

Ki-67 expression and prognosis for smokers with resected stage i Non–Small cell lung cancer Yukiko Haga, MD, Kenzo Hiroshima, MD, Akira Iyoda, MD, Kiyoshi.

Volume 4, Issue 5, Pages (June 2018)

Hepatoid Carcinoma of the Lung with Anaplastic Lymphoma Kinase Gene Rearrangement Sean Khozin, MD, Mark J. Roth, MD, Arun Rajan, MD, Karen Smith, MD,

Imprint Cytology for Detecting Metastasis of Lung Cancer in Mediastinal Lymph Nodes Kenichi Okubo, MD, Tatsuo Kato, MD, Akira Hara, MD, Naoki Yoshimi,

Mariano Garcı́a-Yuste, MD, José M

Metastatic atrial myxoma to the skin at 15 years after surgical resection Yasushi Terada, MD, Yasuhiko Wanibuchi, MD, Masayuki Noguchi, MD, Toshio Mitsui,

Primary Pulmonary Lymphoma

Adnan M. Al-Ayoubi, MD, Jonathan S. Ralston, MD, S

Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: prognosis after complete resection and systematic.

Radiologic Response to Neoadjuvant Treatment Predicts Histologic Response in Thymic Epithelial Tumors Geoffrey B. Johnson, MD, PhD, Marie Christine Aubry,

Meningioma Metastatic to the Lung

Relation Between Thin-Section Computed Tomography and Clinical Findings of Mucinous Adenocarcinoma Hajime Watanabe, MD, Haruhiro Saito, MD, Tomoyuki.

Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty- seven cases Hidefumi Takei, MDa,b, Hisao Asamura, MDb, Arafumi Maeshima,

The evaluation of lymph node metastasis by endobronchial ultrasound-guided transbronchial needle aspiration: Crucial for selection of surgical candidates.

Expression of vascular endothelial growth factor in thoracic sarcomas

Atypical Presentation of Extranodal Rosai-Dorfman Disease

Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity Akira Iyoda, MD, Kenzo Hiroshima, MD, Yasumitsu Moriya, MD, Teruaki.

Thymic neuroendocrine carcinoma (carcinoid): A clinicopathologic study of fourteen cases Vincent Thomas de Montpréville, MDa, Paolo Macchiarini, MDb,

Discriminant Model for Cytologic Distinction of Large Cell Neuroendocrine Carcinoma from Small Cell Carcinoma of the Lung Rira Hoshi, CT, Noriyuki Furuta,

Bronchial Oncocytoma With High 18F-Fluorodeoxyglucose Uptake Revealed by Nephrotic Syndrome Giovanni Leuzzi, MD, Alfredo Cesario, MD, Marco Chiappetta,

Prognostic Impact of Node Involvement Pattern in Pulmonary pN1 Squamous Cell Carcinoma Patients Masayuki Nakao, MD, Junji Yoshida, MD, PhD, Genichiro.

Nael Martini, MDa, Muhammad B. Zaman, MDb, Manjit S

Clinicopathologic Features and Computed Tomographic Findings of 52 Surgically Resected Adenosquamous Carcinomas of the Lung Yukio Watanabe, MD, Koji.

Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic.

Catherine C. Roberts, M. D. , Thomas V. Colby, M. D. , Kenneth P

Primary Pulmonary Rhabdomyosarcoma in an Adult With Neurofibromatosis-1 Jae-Sung Choi, MD, PhD, Jong Sun Choi, MD, PhD, Eung-Joong Kim, MD, PhD The Annals.

A Nonresponding Small Cell Lung Carcinoma

Pleuropulmonary blastoma: is prophylactic resection of congenital lung cysts effective? Konstantinos A Papagiannopoulos, Mary Sheppard, Andrew P Bush,

Vascular Leiomyoma of the Pulmonary Artery

Chondroid Syringoma: A Rare Tumor of the Chest Wall

The Prognostic Importance of Immunohistochemically Detected Node Metastases in Resected Esophageal Adenocarcinoma Tara A. Waterman, BA, Jeffrey A. Hagen,

Primary Pulmonary Meningioma First Suspected of Being a Lung Metastasis Jean Picquet, MD, Isabelle Valo, MD, Yann Jousset, MD, Bernard Enon, MD The Annals.

Dan J. Raz, MD, Jason A. Zell, DO, MPH, Anthony N

Predictors of Survival After Operation Among Patients With Large Cell Neuroendocrine Carcinoma of the Lung Florian Eichhorn, MD, Hendrik Dienemann, MD,

Thymic neuroendocrine tumor (thymic carcinoid): a clinicopathologic study in 15 patients Ichiro Fukai, MD, Akira Masaoka, MD, PhD, Yoshitaka Fujii, MD,

Baoxing Liu, MD, Qiang Pu, MM, Lunxu Liu, MD, Guowei Che, MD

Neal S Goldstein, MD The Annals of Thoracic Surgery

Neuroendocrine Cancer of the Lung: A Diagnostic Puzzle

Volume 5, Issue 5, Pages (May 2019)

Malignant Invasive Thymoma in the Posterior Mediastinum

Pulmonary infarct cytologically mimicking adenocarcinoma of the lung

Analysis of Differentially Expressed Genes in Neuroendocrine Carcinomas of the Lung Chigusa Okubo, MS, Yuko Minami, MD, Ryota Tanaka, MD, Teruhito Uchihara,

Concurrent Metastatic Thymic Carcinoma and Postirradiation Sarcoma

Circulating Tumor Cells in Diagnosing Lung Cancer: Clinical and Morphologic Analysis Alfonso Fiorelli, MD, PhD, Marina Accardo, MD, Emanuele Carelli,

Bronchopulmonary Carcinoid Tumor Associated with Cushing Syndrome

Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non–small cell carcinoma Akira Iyoda, MD, Kenzo.

Presentation transcript:

Pulmonary large cell carcinomas with neuroendocrine features are high-grade neuroendocrine tumors Akira Iyoda, MD, Kenzo Hiroshima, MD, Masayuki Baba, MD, Yukio Saitoh, MD, Hidemi Ohwada, MD, Takehiko Fujisawa, MD The Annals of Thoracic Surgery Volume 73, Issue 4, Pages 1049-1054 (April 2002) DOI: 10.1016/S0003-4975(01)03616-5

Fig 1 Histological features of typical carcinoid. Light microscopy (hematoxylin and eosin stain, ×40). The tumor cells reveal growth patterns such as organoid, palisading, or rosette-like arrangements, which suggest neuroendocrine differentiation. These tumor cells have uniform cytologic features with eosinophilic, finely granular cytoplasm and nuclei with a finely granular chromatin pattern. Typical carcinoids have less than two mitoses per 2 mm2 and lack necrosis. The Annals of Thoracic Surgery 2002 73, 1049-1054DOI: (10.1016/S0003-4975(01)03616-5)

Fig 2 Histological features of atypical carcinoid. Light microscopy (hematoxylin and eosin stain, ×40). The tumor cells reveal growth patterns such as typical carcinoid. However, atypical carcinoids have 2 to 10 mitoses per 2 mm2 and/or necrosis. The Annals of Thoracic Surgery 2002 73, 1049-1054DOI: (10.1016/S0003-4975(01)03616-5)

Fig 3 Histological features of large cell neuroendocrine carcinoma. Light microscopy (hemotoxylin and eosin stain, ×40). The tumor cells have a neuroendocrine morphology with organoid nesting, palisading, and rosettes. Numerous mitoses, which are 11 or greater per 2 mm2, are seen. Cytologic features include large cell size, low nuclear-to-cytoplasmic ratio, fine chromatin, and nucleoli. The Annals of Thoracic Surgery 2002 73, 1049-1054DOI: (10.1016/S0003-4975(01)03616-5)

Fig 4 Histological features of large cell neuroendocrine carcinoma. Immunohistochemistry (×40). The tumor cells stain positive with a polyclonal anti-chromogranin A antibody. The Annals of Thoracic Surgery 2002 73, 1049-1054DOI: (10.1016/S0003-4975(01)03616-5)

Fig 5 Histological features of small cell carcinoma. Light microscopy (hematoxylin and eosin stain, ×40). The tumors consist of small cells, which are round, oval, and spindle-shaped, and generally less than the diameter of three small resting lymphocytes, with scant cytoplasm, ill-defined cell borders, finely granular nuclear chromatin, and absent or inconspicuous nucleoli. The Annals of Thoracic Surgery 2002 73, 1049-1054DOI: (10.1016/S0003-4975(01)03616-5)

Fig 6 The overall survival curves for each tumor histological type. The overall survival for patients with atypical carcinoid was significantly higher than for those with large cell carcinoma with neuroendocrine features (p < 0.001) and with small cell lung carcinoma (p < 0.001). (AC = atypical carcinoid; LCNF = large cell carcinoma with neuroendocrine features; SCLC = small cell lung carcinoma; TC = typical carcinoid.) The Annals of Thoracic Surgery 2002 73, 1049-1054DOI: (10.1016/S0003-4975(01)03616-5)

Fig 7 The disease-free survival curves for each tumor histological type. The disease-free survival for patients with atypical carcinoid was significantly higher than for those with large cell carcinoma with neuroendocrine features (p < 0.001) and small cell lung carcinoma (p < 0.001). (AC = atypical carcinoid; LCNF = large cell carcinoma with neuroendocrine features; SCLC = small cell lung carcinoma; TC = typical carcinoid.) The Annals of Thoracic Surgery 2002 73, 1049-1054DOI: (10.1016/S0003-4975(01)03616-5)