Response to two identical exercise tests (T1 and T2) in 278 adults and 95 children with signs and symptoms of asthma but no definite diagnosis. Response.

Slides:



Advertisements
Similar presentations
Clinical Characteristics of the Saguenay–Lac- St-Jean Familial Collection Subjects Families ProbandsAffected relativesUnaffected relatives n = 253n = 379n.
Advertisements

22/06/2011.  Asthma – an introduction (Vanessa)  Diagnosis and management of chronic asthma in line with current BTS guidelines (Dr Lowery)  3 x Case.
BREATHING By the end of this lesson, I will be able to: Know what tidal volume is. Understand the effects of exercise on breathing.
Dr. Taj. What is Spirometry ? It is a measurement of the breathing capacity of the lungs. It is the most basic and frequently performed test of pulmonary.
Pulmonary function tests & Lung volumes & capacities Prof. Omer Abdel Aziz.
Date of download: 6/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Obstructive Lung Disease and Low Lung Function in.
Bronchial Hyperresponsiveness in the Assessment of Asthma Control
Copyright © 2015 by the American Osteopathic Association.
Bronchial Hyperresponsiveness in the Assessment of Asthma Control
Pulmonary response in sarcoidosis
The ABCs of Asthma Control
Examples of computerised incentives used in spirometry
Least squares (LS) mean change from baseline (95% CI) in trough forced expiratory volume in 1 s (FEV1) according to chronic obstructive pulmonary disease.
Correlation of excessive reactive oxygen species (ROS) production to clinical disease severity. Correlation of excessive reactive oxygen species (ROS)
The EASI model structured around four modules (exposure (top left), activity (bottom left), severity (top right) and impact (bottom right)), each of which.
Summary findings regarding the efficacy/safety profile across xanthines in chronic obstructive pulmonary disease patients. a) Combined plot of the change.
Relationship between the change in a) ventilatory and b) cerebrovascular responses in older healthy subjects (Older) and chronic obstructive pulmonary.
Change from baseline in trough forced expiratory volume in 1 s (FEV1) (per-protocol population). Change from baseline in trough forced expiratory volume.
Distribution of forced expiratory volume in 1 s (FEV1) relative to Global Lung Function Initiative reference values (GLI2012) [10] expressed as FEV1 %
Forced expiratory volume in 1 s (FEV1) results in the RECOVER trial.
Flow diagram summarising the most important effects of biochemical (left) and mechanical (right) pregnancy-induced factors on pulmonary function, ventilatory.
The values for the provoking dose of mannitol to cause a 15% decrease (PD15) in forced expiratory volume in 1 s (FEV1) showing the different levels of.
Immunostaining for lipid peroxidation product 4-hydroxy-2-nonenal (4-HNE) adduct in the lungs of smokers with and without chronic obstructive pulmonary.
A) Exhaled nitric oxide fraction (FeNO) before and after 9 weeks of treatment; b) percentage change in forced expiratory volume in 1 s (FEV1) following.
Virus shedding after human rhinovirus infection in children, adults and patients with hypogammaglobulinaemia  V. Peltola, M. Waris, L. Kainulainen, J.
Change from baseline following beclomethasone/formoterol and placebo in a) platelet–monocyte aggregate formation, b) P-selectin expression and c) platelet.
A) In the presence of Aspergillus fumigatus, local IgA and IgG levels to A. fumigatus are significantly elevated; *: p
A) Peak forced expiratory volume in 1 s within 3 h post-dosing (peak FEV10–3h) response following once-daily tiotropium Respimat add-on to medium-dose.
Michael E. Wechsler, MD  Mayo Clinic Proceedings 
Schematic representation of breathing levels during positive expiratory pressure in an obstructed patient. Schematic representation of breathing levels.
Changes of a) spirometric, plethysmographic, and b) impedance data at 5 Hz induced by bronchodilator in flow limited (□) and nonflow limited (▓) patients.
Risk of bias summary for Cochrane review comparing pMDI and spacer to nebulisers to deliver β2-agonists to adults and children with acute asthma. Risk.
Forest plot showing the number of adults (at the top) and children (lower down) who were admitted to hospital after treatment in the emergency department.
Change in lung clearance index (LCI) (mean±sd % change lung turnovers compared with baseline) based on modelled a, b) continuous and c, d) isolated pre-capillary.
Expanded version of the early part of a subject's volume–time spirogram, illustrating back-extrapolation through the steepest part of the curve, where.
Representative diaphragm electromyogram (EMG) tracings at rest (a and b) and during maximum voluntary ventilation (c and d) in a healthy subject (a and.
Changes in operating lung volumes are shown as ventilation increases with exercise in a) age-matched normal subjects (n = 25) and b) chronic obstructive.
Least squares (LS) mean change from baseline (95% CI) in trough forced expiratory volume in 1 s (FEV1) according to exacerbation history (intent-to-treat.
The events that lead to airway narrowing and a reduction in forced expiratory volume in 1 s in response to different indirect challenge tests. The events.
Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985–2005  F.A. Millar, N.J. Simmonds, M.E. Hodson  Journal.
Flow–volume loop analysis
James H. Hull, Rachel Garrod, Timothy B. Ho, Ronald K. Knight, John R
Design of adult and paediatric studies investigating the efficacy and tolerability of ivacaftor [16, 17]. Design of adult and paediatric studies investigating.
Capnography traces. a) A good-quality trace showing a clear plateau that will ensure an accurate measurement of ETCO2. b) A trace from a patient with airflow.
What the asthma end points we know and love do and do not tell us
Post-bronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio in subjects aged >50 yrs. Post-bronchodilator forced expiratory.
Forest plot meta-analysis of the impact of long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combinations on changes in.
Relationship between bronchodilator response of physiological parameters and concentration of interleukin (IL)-8 in epithelial lining fluid (ELF). Relationship.
Comparison between prediction equations from Wang et al
Recordings of quiet tidal breathing at rest, followed by maximal expiration then inspiration. Recordings of quiet tidal breathing at rest, followed by.
Decline of lung function of a LTX patient who rapidly developed severe BOS at our centre. Decline of lung function of a LTX patient who rapidly developed.
Physician perspectives on the most useful methods for monitoring α1-antitrypsin deficiency in the clinical trial setting versus clinical practice. Physician.
Scatter plot of body mass index (BMI) versus forced expiratory volume in the first second (FEV1), and linear correlation lines for normal spirometry and.
Change in physiological variables from baseline values a) at rest and b) during exercise after saline infusion and exposition to different β-blocker agents.
Relationship between a) forced expiratory flow at 25–75% of forced vital capacity (FVC) (FEF25–75%) and b) forced expiratory flow at 75% of FVC (FEF75%)
A) Forced expiratory volume in 1 s (FEV1) and b) 6-min walk test (6MWT) distance by bronchiectasis in any lobe/vascular pruning in the lower lobes groups.
Cumulative mortality over 60 months in patients with α1-antitrypsin deficiency and an initial forced expiratory volume in 1 s
Lung function adjusted for body length and gestational age in male and female premature infants. Lung function adjusted for body length and gestational.
Adjusted mean±se response in peak forced expiratory volume in 1 s within 3 h post-dosing (peak FEV10–3h) at week 24, following once-daily tiotropium Respimat.
The European population from 1950 to 2050, with estimated population before 2006 (light background) and projected population (dark background). The European.
Technegas® ventilation single photon emission computed tomography images of an asthmatic subject (axial slices) at a) baseline and b) post-methacholine.
Scatterplots showing baseline correlation between forced expiratory volume in 1 s (FEV1) % pred and a) COPD Assessment Test (CAT), b) Clinical COPD Questionnaire.
A) Operating lung volumes and b) breathing frequency (Fb) during incremental cycle exercise in patients with moderate chronic obstructive pulmonary disease.
Absolute change in forced expiratory volume in 1 s (FEV1) % pred over time in clinical trials with a) ivacaftor (IVA) in patients with at least one G551D.
Effects of reslizumab on lung function (forced expiratory volume in 1 s; FEV1) in Global Initiative for Asthma (GINA) Step 4 and 5 patients. Effects of.
Interleukin (IL)-1β and IL-18 in stable chronic obstructive pulmonary disease (COPD) patients. a) IL-1β and IL-18 relative transcript levels in lung tissues.
Flow–volume loops of test breaths and preceding control breaths of three representative chronic obstructive pulmonary disease patients with different degrees.
Study design for ECLIPSE (VX-659 triple combination) and AURORA (VX-445 triple combination) phase 3 studies. Study design for ECLIPSE (VX-659 triple combination)
Comparison of pre- and post-bronchodilator data for spirometric and oscillometric parameters. Comparison of pre- and post-bronchodilator data for spirometric.
Tracing of tidal breathing followed by an inspiratory manoeuvre to total lung capacity (TLC) to record inspiratory capacity (IC), followed by a full expiration.
Presentation transcript:

Response to two identical exercise tests (T1 and T2) in 278 adults and 95 children with signs and symptoms of asthma but no definite diagnosis. Response to two identical exercise tests (T1 and T2) in 278 adults and 95 children with signs and symptoms of asthma but no definite diagnosis. Note that for 89 subjects, the exercise test was positive on only one of the two tests. For 44 subjects, the negative test was the first one and thus on one test exercise-induced bronchoconstriction would have been missed. FEV1: forced expiratory volume in 1 s Modified from [10] under creative commons. S.D. Anderson breathe 2011;8:53-60 ©2011 by European Respiratory Society