Pulmonary Blastoma with Renal Metastasis Responds to Sorafenib

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Presentation transcript:

Pulmonary Blastoma with Renal Metastasis Responds to Sorafenib Keerthi Mulamalla, MD, Alexander M. Truskinovsky, MD, Arkadiusz Z. Dudek, MD, PhD Journal of Thoracic Oncology Volume 2, Issue 4, Pages 344-347 (April 2007) DOI: 10.1097/01.JTO.0000263719.76944.0a Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Pulmonary blastoma metastasis to the kidney (4.2 × 4.5 cm) before treatment with sorafenib (January 2006). Journal of Thoracic Oncology 2007 2, 344-347DOI: (10.1097/01.JTO.0000263719.76944.0a) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Pulmonary blastoma metastasis to the kidney (2.0 × 3.5 cm) after 2 months of treatment with sorafenib (March 2006). Journal of Thoracic Oncology 2007 2, 344-347DOI: (10.1097/01.JTO.0000263719.76944.0a) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Mesenchymal component of the pulmonary blastoma in the chest wall, resected in May 2004, showing frequent apoptotic bodies (black arrows), solid sheets of small cells with scant cytoplasm, and round to slightly elongated nuclei with clumped chromatin and small nucleoli. Hematoxylin and eosin staining; original magnification ×400. Journal of Thoracic Oncology 2007 2, 344-347DOI: (10.1097/01.JTO.0000263719.76944.0a) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Fetal adenocarcinoma component of the pulmonary blastoma in the chest wall resected in May 2004, with glands lined by pseudostratified columnar epithelium with sub- and supranuclear vacuoles. Hematoxylin and eosin staining; original magnification ×400. Journal of Thoracic Oncology 2007 2, 344-347DOI: (10.1097/01.JTO.0000263719.76944.0a) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 5 Fetal adenocarcinoma component of the pulmonary blastoma in the chest wall resected in May 2004, showing diffuse positive nuclear immunostaining for TTF-1, a pulmonary marker. Hematoxylin and eosin staining; original magnification ×100. Journal of Thoracic Oncology 2007 2, 344-347DOI: (10.1097/01.JTO.0000263719.76944.0a) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 6 Metastatic pulmonary blastoma in the right kidney resected in April 2006 with morphological correspondence to the fetal adenocarcinoma from the chest wall (lower half of field) and squamous differentiation (upper half of field) but no embryonic mesenchyme component. Hematoxylin and eosin staining; original magnification ×400. Journal of Thoracic Oncology 2007 2, 344-347DOI: (10.1097/01.JTO.0000263719.76944.0a) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions