Effects of intracoronary calcium chloride on regional oxygen balance and mechanical function in normal and stunned myocardium in dogs K.Y. Yoo, J.U.

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Effects of intracoronary calcium chloride on regional oxygen balance and mechanical function in normal and stunned myocardium in dogs K.Y. Yoo, J.U. Lee, S.H. Kwak, W.M. Im, C.Y. Jeong, S.S. Chung, M.H. Yoon, S.W. Jeong, J.T. Park British Journal of Anaesthesia Volume 88, Issue 1, Pages 78-86 (January 2002) DOI: 10.1093/bja/88.1.78 Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 Schematic presentation of the experimental preparation. LAD=left anterior descending coronary artery; LCX=left circumflex coronary artery; IVC=intravenous catheter; IAC=intra-arterial catheter; UDT=ultrasonic dimension transducers. British Journal of Anaesthesia 2002 88, 78-86DOI: (10.1093/bja/88.1.78) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 2 Relationship between myocardial oxygen consumption (MV˙O2) and coronary blood flow (CBF) during intracoronary calcium chloride infusion in normal and stunned myocardium in enflurane anaesthetized dogs (n=13). In both normal and stunned myocardium, CBF increased in parallel with MV˙O2. British Journal of Anaesthesia 2002 88, 78-86DOI: (10.1093/bja/88.1.78) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 3 Effects of calcium chloride on lactate extraction (Elac) in normal and stunned myocardium in enflurane-anaesthetized dogs (n=13). Elac was not significantly affected by calcium chloride either in normal or stunned myocardium. Data are skewed and therefore presented as a dot plot with mean (sd). The ischaemia and reperfusion insult itself significantly reduced Elac. †P<0.05 compared with normal myocardium. British Journal of Anaesthesia 2002 88, 78-86DOI: (10.1093/bja/88.1.78) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 4 Changes [mean (sd)] from preischaemic baseline values of %SS, MV˙O2, CBF and EO2 during calcium chloride infusion in stunned myocardium in dogs anaesthetized with enflurane (n=13) or fentanyl–midazolam (n=5). Changes were similar in the two groups. †P<0.05 compared with preischaemic baseline values; *P<0.05 compared with postischaemic baseline values (indicated as dose 0 of calcium chloride). British Journal of Anaesthesia 2002 88, 78-86DOI: (10.1093/bja/88.1.78) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions