Tertiary and Quaternary Protein Structure

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Presentation transcript:

Tertiary and Quaternary Protein Structure

Primary and Secondary Structure Primary protein structure- Described by the sequence of amino acids joined by peptide bonds. Secondary protein structure- Common structural motifs. eg. Alpha helices, Beta sheets

So What’s Tertiary Structure Tertiary structure is the overall shape of a single peptide strand.

Example Tertiary Structure

Same Protein, Different View

Same Protein, Yet Another View

One Final Look

What Determines Tertiary Structure? Usually interactions between atoms in the R groups of the peptide chain. Typically there is not a repeating pattern of bonding that determines the structure.

Common Interactions Determining Tertiary Structure. Image removed

Quaternary Structure The overall structure of a protein made up of more than one peptide chain. Same interactions forming tertiary structure are responsible for forming the quaternary structure of a protein.

Image Removed

Factors Affecting Structure Temperature- High temperature overcomes hydrogen bonds pH- protonation and deprotonation of acidic and basic residues Salinity- affects hydration of the protein and bonding.

So what do proteins do? Your turn Myoglobin Collagen Potassium channel Monoamine oxidase Insulin Immunoglobulin

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Image References Protein Data Bank Proteins: 2a5t & 2a5s PowerPoint Lectures Exclusively for Adpoters of Campbell and Reece Biology, 6th Edition. 2002, Benjamin Cummings