Fig. 8 TLR8 exacerbates disease in the BLM-induced fibrosis model.

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Fig. 8 TLR8 exacerbates disease in the BLM-induced fibrosis model. TLR8 exacerbates disease in the BLM-induced fibrosis model. (A) Representative images of Masson’s trichrome–stained skin sections at a magnification of ×10 of WT mice injected with PBS or WT mice, Tg8 mice, TLR7KO mice, and Tg8 × TLR7KO (Tg8 × 7KO) mice injected with BLM. (B) Average of skin thickness (n = 11 to 18 per group). (C) Representative images of Siglec-H+ cells in the skin of WT mice injected with PBS or with BLM and of Tg8 mice, TLR7KO mice, and Tg8 × TLR7KO mice injected with BLM. (D) Histograms represent number of Siglec-H+ cells and are cumulative of at least 10 mice from three independent experiments. (E and F) Relative expression of indicated genes regulated by TLR8 and/or TLR7 using the NanoString technology. (G and H) Gene expression levels of huTLR8 by qPCR for (G) macrophages (F4/80+, CD11b+) or (H) pDCs (F4/80−, CD11b− and B220+, Siglec-H+, BST2+) purified from WT or Tg8 mice (n = 3 to 4) that received PBS or 4 weeks of BLM as indicated (see Materials and Methods). All results are represented as means ± SEM from three to six independent experiments for each group, and statistical significance was evaluated using a Mann-Whitney U test. *P < 0.05, **P < 0.01, ***P < 0.001. Marie Dominique Ah Kioon et al., Sci Transl Med 2018;10:eaam8458 Published by AAAS