Replenishing Regulatory T Cells to Halt Depigmentation in Vitiligo

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Replenishing Regulatory T Cells to Halt Depigmentation in Vitiligo I. Caroline Le Poole, Shikhar Mehrotra Journal of Investigative Dermatology Symposium Proceedings Volume 18, Issue 2, Pages S38-S45 (October 2017) DOI: 10.1016/j.jisp.2016.10.023 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Examples of vitiligo in skin of different origins. Vitiligo is a skin disease that can occur in patients of any ethnicity, yet its presence is most readily noticeable in people with darker skin tones. Examples with country of origin are shown. Journal of Investigative Dermatology Symposium Proceedings 2017 18, S38-S45DOI: (10.1016/j.jisp.2016.10.023) Copyright © 2016 The Authors Terms and Conditions

Figure 2 IFN-γ drives depigmentation in vitiligo-prone h3TA2 mice. On an IFN-γ–knockout background, no depigmentation is observed, whereas a lack of pigment in the skin and hair of h3TA2 mice is readily apparent. Depigmentation in the IFN-γ–knockout mice was restored by depleting Tregs (not shown). Journal of Investigative Dermatology Symposium Proceedings 2017 18, S38-S45DOI: (10.1016/j.jisp.2016.10.023) Copyright © 2016 The Authors Terms and Conditions

Figure 3 Limited abundance of Tregs in the skin of vitiligo-prone h3TA2 mice. FoxP3+ CD3+ Tregs compared in skin homogenates from A2 and h3TA2 mice. Abundance of Tregs identified as FoxP3+ CD3+ lymphocytes among cells infiltrating the skin shows markedly (∼20-fold) reduced Tregs in h3TA2 mice. SSC, side scatter; FSC, forward scatter. Journal of Investigative Dermatology Symposium Proceedings 2017 18, S38-S45DOI: (10.1016/j.jisp.2016.10.023) Copyright © 2016 The Authors Terms and Conditions

Figure 4 Skin-homing Tregs in healthy skin express cutaneous lymphocyte antigen (CLA). In adult human skin (left), intense red staining for FoxP3 to locate Tregs in the skin is accompanied by membrane expression of CLA as detected by antibody Heca452 in blue. By contrast, CLA+ T cells in nonlesional vitiligo skin (right) are not Tregs. Scale bars = 100 μm. Journal of Investigative Dermatology Symposium Proceedings 2017 18, S38-S45DOI: (10.1016/j.jisp.2016.10.023) Copyright © 2016 The Authors Terms and Conditions