A “No-wash” Albumin-Dextran Dilution Strategy for Cord Blood Unit Thaw: High Rate of Engraftment and a Low Incidence of Serious Infusion Reactions Juliet.

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A “No-wash” Albumin-Dextran Dilution Strategy for Cord Blood Unit Thaw: High Rate of Engraftment and a Low Incidence of Serious Infusion Reactions Juliet N. Barker, Michelle Abboud, Robert D. Rice, Rebecca Hawke, Allison Schaible, Glenn Heller, Vincent La Russa, Andromachi Scaradavou Biology of Blood and Marrow Transplantation Volume 15, Issue 12, Pages 1596-1602 (December 2009) DOI: 10.1016/j.bbmt.2009.08.009 Copyright © 2009 Terms and Conditions

Figure 1 Distribution of infused DMSO doses/kg with double-unit CB grafts prepared with albumin dilution and incidence of infusion reactions in 53 patients. To most accurately represent the DMSO dose with two unwashed units the single patient who received 1 washed unit is excluded from this analysis. Biology of Blood and Marrow Transplantation 2009 15, 1596-1602DOI: (10.1016/j.bbmt.2009.08.009) Copyright © 2009 Terms and Conditions

Figure 2 Cumulative incidence of sustained neutrophil engraftment (A) and platelet engraftment (B) after CBT with double-unit grafts prepared with albumin-dextran dilution. Recipients of ablative and nonmyeloablative conditioning are shown separately. Although early recovery in recipients of nonmyeloablative conditioning resulted from transient autologous recovery, all engrafting patients shown converted to sustained donor-derived hematopoiesis. Biology of Blood and Marrow Transplantation 2009 15, 1596-1602DOI: (10.1016/j.bbmt.2009.08.009) Copyright © 2009 Terms and Conditions

Figure 3 Kaplan-Meier probabilities of OS and DFS after CBT with double unit grafts prepared with albumin-dextran dilution. Biology of Blood and Marrow Transplantation 2009 15, 1596-1602DOI: (10.1016/j.bbmt.2009.08.009) Copyright © 2009 Terms and Conditions