Dylan R. Nieman, MD, PhD, Christian G. Peyre, MD, Thomas J

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Neoadjuvant Treatment Response in Negative Nodes Is an Important Prognosticator After Esophagectomy Dylan R. Nieman, MD, PhD, Christian G. Peyre, MD, Thomas J. Watson, MD, Wenqing Cao, MD, Michael D. Lunt, MD, Michal J. Lada, MD, Michelle S. Han, MD, Carolyn E. Jones, MD, Jeffrey H. Peters, MD The Annals of Thoracic Surgery Volume 99, Issue 1, Pages 277-283 (January 2015) DOI: 10.1016/j.athoracsur.2014.07.037 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Histologic evidence of lymph node treatment effect. Representative hematoxylin and eosin–stained lymph nodes (magnification ×40) with histologic evidence of prior cancer involvement, including (A) calcification and necrosis, (B) central fibrosis, or (C) acellular mucin. The Annals of Thoracic Surgery 2015 99, 277-283DOI: (10.1016/j.athoracsur.2014.07.037) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Survival curve by nodal status: no evidence of nodal disease at any time (negative, solid line), treatment-response nodes (TRN) with evidence of prior nodal involvement but without viable cancer cells detected (dashed line) or with evidence of active nodal malignancy (positive, dashed-dot line). The Annals of Thoracic Surgery 2015 99, 277-283DOI: (10.1016/j.athoracsur.2014.07.037) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Survival curves (A) by stage using the traditional American Joint Committee on Cancer staging criteria, (B) by stage (0-1, solid line; 2, dashed line; 3, dash-dot line) counting treatment-response nodes (TRN) as involved nodes, (C) in patients with no or limited nodal involvement (N0 or N1), comparing patients with (dashed line) and without (solid line) TRN-positive nodes, and (D) in patients with limited stage disease (0-2B) comparing patients with (dashed line) and without (solid line) TRNs. The Annals of Thoracic Surgery 2015 99, 277-283DOI: (10.1016/j.athoracsur.2014.07.037) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions