Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome? Ruzena.

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Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome? Ruzena Tkacova, MD, PhD, Darlene L.Y. Dai, MSc, Judith M. Vonk, PhD, Janice M. Leung, MD, Pieter S. Hiemstra, PhD, Maarten van den Berge, MD, PhD, Lisette Kunz, MD, Zsuzsanna Hollander, PhD, Donald Tashkin, MD, Robert Wise, MD, John Connett, PhD, Raymond Ng, PhD, Bruce McManus, MD, PhD, S.F. Paul Man, MD, Dirkje S. Postma, MD, PhD, Don D. Sin, MD Journal of Allergy and Clinical Immunology Volume 138, Issue 6, Pages 1571-1579.e10 (December 2016) DOI: 10.1016/j.jaci.2016.04.022 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Decline in FEV1 (A) and absolute FEV1 (B) in patients with COPD with AHR and without AHR (black, PC20 cutoff of 4 mg/mL; red, PC20 cutoff of 15 mg/mL) in the LHS. Journal of Allergy and Clinical Immunology 2016 138, 1571-1579.e10DOI: (10.1016/j.jaci.2016.04.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Estimates of cumulative incidence of respiratory mortality (A), cardiovascular disease (CVD) mortality (B), and total mortality (C) for patients with COPD with AHR and without AHR (non-AHR) (black, PC20 cutoff of 4 mg/mL; red, PC20 cutoff of 15 mg/mL). For each plot, x-axis is follow-up in years from the date of blood draw to the end of the passive follow-up of the LHS and y-axis is the probability of mortality for a given time. Journal of Allergy and Clinical Immunology 2016 138, 1571-1579.e10DOI: (10.1016/j.jaci.2016.04.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 AIC of respiratory death, indicating the best goodness of fit, of different thresholds of PC20. Journal of Allergy and Clinical Immunology 2016 138, 1571-1579.e10DOI: (10.1016/j.jaci.2016.04.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Decline in FEV1 (boxplots) in patients with COPD with AHR and without AHR (PC20 cutoff of 4 mg/mL) in the LHS. Journal of Allergy and Clinical Immunology 2016 138, 1571-1579.e10DOI: (10.1016/j.jaci.2016.04.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 AIC for FEV1 decline, indicating the best goodness of fit, of different thresholds of PC20—linear model (A), and treating time as a discrete variable (B). Journal of Allergy and Clinical Immunology 2016 138, 1571-1579.e10DOI: (10.1016/j.jaci.2016.04.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Receiver operating characteristic curves of airway responsiveness (PC20), BDR, and smoking status for FEV1 decline of more than 120 mL over 3 years. Journal of Allergy and Clinical Immunology 2016 138, 1571-1579.e10DOI: (10.1016/j.jaci.2016.04.022) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions