Fig. 2 Stroke increases vascular inflammation via recruitment of inflammatory monocytes to atherosclerotic plaques. Stroke increases vascular inflammation.

Slides:

Advertisements

Similar presentations

Lukasova M. et al. J Clin Invest 2011;121:

Advertisements

AB C D E F G H Supplemental Fig. 1. Figure S1. MIF induces maturation of CD11b + but not CD8α + DCs in spleen from Mif -/- mice infected with T. gondii.

Interleukin 12 Induces T-Cell Recruitment Into the Atherosclerotic Plaque by Xiaoyu Zhang, Alexander Niessner, Takako Nakajima, Wei Ma-Krupa, Stephen L.

TRAF5 Deficiency Accelerates Atherogenesis in Mice by Increasing Inflammatory Cell Recruitment and Foam Cell FormationNovelty and Significance by Anna.

LTB4 production is elevated in preclinical and clinical lymphedema

Fig. 2. LUM015 fluorescently labels tumor cells in mouse models of STS and breast cancer. LUM015 fluorescently labels tumor cells in mouse models of STS.

Therapeutic distant organ effects of regional hypothermia during mesenteric ischemia- reperfusion injury Rachel J. Santora, MD, Mihaela L. Lie, MD, Dmitry.

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses by Ruth A. Ettinger,

Volume 20, Issue 8, Pages (August 2017)

Frederic Geissmann, Steffen Jung, Dan R. Littman Immunity

Fig. 4 Bacterial taxonomic groups that discriminate among RYGB-, SHAM-, and WMS-derived samples. Bacterial taxonomic groups that discriminate among RYGB-,

Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.

David Voehringer, Kanade Shinkai, Richard M Locksley Immunity

Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.

Fig. 2. Engraftment of CART-EGFRvIII and cytokine modulation in the peripheral blood. Engraftment of CART-EGFRvIII and cytokine modulation in the peripheral.

B-cell differentiation associates with down-regulation of vimentin expression. B-cell differentiation associates with down-regulation of vimentin expression.

Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.

Fig. 1 pDCs infiltrate the skin of SSc patients and spontaneously secrete IFN-α and CXCL4. pDCs infiltrate the skin of SSc patients and spontaneously secrete.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Fig. 1. Identification of SE-associated lncRNAs.

Maraba treatment sensitizes 4T1 tumors to immune checkpoint blockade

Fig. 2. GPC3 expression in normal and tumor tissues.

Fig. 6. Effects of CD31-NP targeting in perfused human kidneys.

Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta Zhenjie Liu, MD, PhD, Qiwei Wang,

Fig. 5 A competent Fc is required for the antitumor immune response.

Fig. 4. Specific versus nonspecific NP accumulation.

Fig. 2 Systemically released inflammatory factors directly affect HSC-e cell fate. Systemically released inflammatory factors directly affect HSC-e cell.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

Volume 140, Issue 5, Pages e3 (May 2011)

Volume 29, Issue 2, Pages (August 2008)

Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells Cathryn A. Weston, PhD, Batika M.J. Rana,

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

PS202. Propagermanium, a CCR2 Signaling Inhibitor, Suppresses Monocyte Mobilization and Migration in Experimental Aneurysms Naoki Fujimura, Baohui Xu,

Fig. 7. ApoMSCs exert immunosuppressive activity in GvHD and elicit IDO in engulfing recipient phagocytes. ApoMSCs exert immunosuppressive activity in.

Fig. 4. Improved tumor response to docetaxel in TNBC and trastuzumab in HER2-amplified PDX models with the addition of S Improved tumor response.

Fig. 7 Improvement of clinical score and axon pathology by nasal IL-4 treatment during chronic EAE. Improvement of clinical score and axon pathology by.

Mohamed A. Saleh et al. BTS 2016;1:

Fig. 6 Alarmin release and sympathetic stress response synergize in poststroke atheroprogression. Alarmin release and sympathetic stress response synergize.

Stroke induces atheroprogression via the RAGE-signaling pathway

Inflammatory APC show highest expression of TNF superfamily ligands in the lung after LCMV infection. Inflammatory APC show highest expression of TNF superfamily.

Fig. 1 Effect of preinfection β7Hi CD45RA−CD4+ T cell frequency on HIV acquisition risk in CAPRISA 004 study. Effect of preinfection β7Hi CD45RA−CD4+ T.

Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.

Fig. 2 Genotype-induced differential gene expression is different in MDMi cells compared to monocytes. Genotype-induced differential gene expression is.

Fig. 4. Features of PH in LLC1 lung tumor mice.

Fig. 4. The effect of single-dose rozanolixizumab on the concentration of IgG subtypes in healthy subjects. The effect of single-dose rozanolixizumab on.

CXCR5 expression accelerates Eμ-Tcl1 leukemogenesis and is indispensable for tumor cell recruitment to lymphoid B-cell follicles. CXCR5 expression accelerates.

Fig. 3. VEGFR-3 signaling increases infiltration of naïve T cells in a CCR7-dependent manner. VEGFR-3 signaling increases infiltration of naïve T cells.

Fig. 2 ALRN-6924 rapidly increases transcription at the p21 locus and affects its bursting dynamics. ALRN-6924 rapidly increases transcription at the p21.

Volume 139, Issue 2, Pages (August 2010)

Fig. 4. Dabrafenib and trametinib changed the cellular components of the tumor microenvironment. Dabrafenib and trametinib changed the cellular components.

Rena Watanabe et al. BTS 2016;1:

Stroke induces inflammatory activation of the aortic endothelium

Fig. 1 Schematic of experimental design.

Karima R.R. Siddiqui, Sophie Laffont, Fiona Powrie Immunity

Fig. 5 Early and modest immune response at day 3 after exposure in Delayed animals. Early and modest immune response at day 3 after exposure in Delayed.

Fig. 5 Treatment with an OX40 agonist antibody of 3-week-old HBVtgRag−/− mice or mice with chronic HBV disease results in an altered immune response to.

David Voehringer, Kanade Shinkai, Richard M Locksley Immunity

Fig. 2. Increased CD19 CAR-T cell expansion and persistence after Cy/Flu lymphodepletion. Increased CD19 CAR-T cell expansion and persistence after Cy/Flu.

Patrolling monocytes control tumor metastasis to the lung

Fig. 2. CD treatment facilitates regression of murine atherosclerosis.

PD-L1 expression is maintained on NCMs under inflammatory conditions and PD-L1+NCMs are found in TLOs. PD-L1 expression is maintained on NCMs under inflammatory.

PD-1 blockade results in increased expression of the chemokine receptor CXCR3. PD-1 blockade results in increased expression of the chemokine receptor.

Fig. 9. SMC-specific Col15a1 knockout resulted in downregulation of immune cell processes that impact atherosclerotic plaque formation. RNA-seq analysis.

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke by Stefan Roth, Vikramjeet Singh, Steffen.

by Ganesh V. Halade, Paul C. Norris, Vasundhara Kain, Charles N

Mechanisms of FRC-dependent myeloid cell recruitment.

Expression of chemokine receptors in A-498 cell line.

Surface expression of chemokine receptors on M

Presentation transcript:

Fig. 2 Stroke increases vascular inflammation via recruitment of inflammatory monocytes to atherosclerotic plaques. Stroke increases vascular inflammation via recruitment of inflammatory monocytes to atherosclerotic plaques. (A) Schematic illustration of experimental design for data shown in (B) to (D): HCD-fed ApoE−/− mice underwent sham or stroke surgery and received either continuous bromdeoxyurdine (BrdU) administration or CCR2RFP/+ bone marrow–derived cells intraperitoneally (ip). After 1 week, mice were sacrificed, and aortas and lymphoid organs were analyzed. (B) Analysis of BrdU+CD11b+ monocytes from aortas after stroke or sham surgery (U test, n = 5 to 7 per group). (C) Gating strategy and representative histogram plots (right) for invading red fluorescent protein–positive (RFP+) monocytes in aortas (white, sham; gray, stroke) and (D) corresponding quantification of RFP+CD11b+ monocytes in aorta (U test, n = 5 to 6 per group). (E) Fold change (FC) and adjusted P values (in parentheses) of chemokine and chemokine receptor transcription in aorta lysates 3 days after stroke compared to sham surgery (left; n = 3 per group, P < 0.1) and corresponding volcano plot for transcriptional regulation determined by real-time polymerase chain reaction arrays (right panel; x axis = fold change; y axis = P value, cutoff at <0.1). (F) Serum levels of CC-chemokine ligand 2 (CCL2) 1 week after stroke compared to sham surgery (U test, n = 4 to 6 per group). (G) Flow cytometric analysis of aortic CCR2+Ly6Chigh monocytes (left) and CC-chemokine receptor type 2–positive (CCR2+) surface expression on inflammatory Ly6Chigh monocytes (right) in aortas 3 days after stroke or sham surgery (U test, n = 7 per group). (H) Quantification of aortic invasion of adoptively transferred RFP-reporter cells from either CCR2-deficient (CCR2RFP/RFP) or CCR2+ RFP+ donor mice (CCR2RFP/+) (U test, n = 5 to 6 per group). Stefan Roth et al., Sci Transl Med 2018;10:eaao1313 Published by AAAS