HEXIM1 Has Different Functions within Different RNA-Protein Complexes

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HEXIM1 Has Different Functions within Different RNA-Protein Complexes Olivier Bensaude Molecular Cell Volume 67, Issue 3, Pages 357-359 (August 2017) DOI: 10.1016/j.molcel.2017.07.021 Copyright © 2017 Terms and Conditions

Figure 1 Two ncRNAs Promote the Assembly of Distinct Complexes on HEXIM1 (Top panel) The HDP-RNP complex is assembled on a HEXIM1/NEAT1 ncRNA platform. DNA detection detaches the HDP-RNP complex from nuclear paraspeckles. DNAPK, TBK1, and IRF3 are phosphorylated (∗), and cGAS synthesizes 2′3′ cGAMP that releases STING from the endoplasmic reticulum. STING then associates with the HDP-RNP complex, assisting IRF3 in activating the transcription of IFN genes. (Bottom panel) The HEXIM1/7SK ncRNA platform binds to and inhibits P-TEFb, thereby controlling elongation of transcription and pre-mRNA processing. 7SK titration or HEXIM1 phosphorylation increases overall P-TEFb activity. Molecular Cell 2017 67, 357-359DOI: (10.1016/j.molcel.2017.07.021) Copyright © 2017 Terms and Conditions