José Luis Lezana, Mario H. Vargas, José Karam-Bechara, Ruth S

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Presentation transcript:

Sweat conductivity and chloride titration for cystic fibrosis diagnosis in 3834 subjects José Luis Lezana, Mario H. Vargas, José Karam-Bechara, Ruth S. Aldana, María E.Y. Furuya Journal of Cystic Fibrosis Volume 2, Issue 1, Pages 1-7 (March 2003) DOI: 10.1016/S1569-1993(02)00146-7

Fig. 1 Relationship between results obtained with the conductivity method and chloride titration in a chloridimeter in sweat samples from 3834 subjects with (closed circles) or without (open circles) cystic fibrosis (chloride >60 mmol/l). rS, Spearman correlation coefficient. Journal of Cystic Fibrosis 2003 2, 1-7DOI: (10.1016/S1569-1993(02)00146-7)

Fig. 2 Frequency distribution of conductivity values in subjects with (closed bars) or without (open bars) diagnosis of cystic fibrosis (chloride >60 mmol/l). Journal of Cystic Fibrosis 2003 2, 1-7DOI: (10.1016/S1569-1993(02)00146-7)

Fig. 3 Receiver operating characteristics curve obtained in 3834 subjects, assessing the capacity of conductivity to predict cystic fibrosis diagnosis (chloride titration >60 mmol/l). Each circle represents a different conductivity cut-off value. The inset shows the complete range of conductivity cut-off values (1–150 mmol/l), while the main panel is a close-up of those cut-off values that achieved better performance, ranging from 94 (left lower corner) to 77 mmol/l (right upper corner). The closed circle shows the best conductivity cut off value (≥90 mmol/l), which yields 99.66% sensitivity without false positive results. Journal of Cystic Fibrosis 2003 2, 1-7DOI: (10.1016/S1569-1993(02)00146-7)

Fig. 4 Relationship between chloride titration value and bias (conductivity minus chloride titration) among subjects with (closed circles) or without (open circles) cystic fibrosis. Journal of Cystic Fibrosis 2003 2, 1-7DOI: (10.1016/S1569-1993(02)00146-7)

Fig. 5 Relationship between chloride titration result and the chloride titration/conductivity ratio in subjects with (closed circles) or without (open circles) cystic fibrosis. Journal of Cystic Fibrosis 2003 2, 1-7DOI: (10.1016/S1569-1993(02)00146-7)