Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study by Sally A Stapley, Greg P Rubin, Deborah Alsina,

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Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study by Sally A Stapley, Greg P Rubin, Deborah Alsina, Elizabeth A Shephard, Matthew D Rutter, and William T Hamilton BJGP Volume ():bjgp17X690425 March 27, 2017 ©2017 by British Journal of General Practice

Inclusion and exclusion of cases and controls in the combined colorectal cancer (CRC) and inflammatory bowel disease (IBD) dataset. Inclusion and exclusion of cases and controls in the combined colorectal cancer (CRC) and inflammatory bowel disease (IBD) dataset. Sally A Stapley et al. Br J Gen Pract doi:10.3399/bjgp17X690425 ©2017 by British Journal of General Practice

PPVs (95% CI) for colorectal cancer (CRC) or inflammatory bowel disease (IBD) in males and females aged 18–49 years for individual risk markers and for pairs of risk markers in combination. PPVs (95% CI) for colorectal cancer (CRC) or inflammatory bowel disease (IBD) in males and females aged 18–49 years for individual risk markers and for pairs of risk markers in combination. The top figure in each cell is the PPV (95% CI) when both features are present. CI have not been calculated when any cell in the 2 × 2 table was <5 (invariably, this was because too few controls had both features). The yellow shading is for features with a PPV >1%; and the red for PPV >3% (see Discussion for reasoning). The cells along the diagonal relate to the PPV when the same feature has been reported twice. Thus, the abdominal pain/abdominal pain intersect is the PPV for CRC/IBD when a patient has attended at least twice with abdominal pain. PPV = positive predictive value. Sally A Stapley et al. Br J Gen Pract doi:10.3399/bjgp17X690425 ©2017 by British Journal of General Practice

PPVs (95% CI) for colorectal cancer (CRC) in males and females aged 18–49 years for individual risk markers and for pairs of risk markers in combination. PPVs (95% CI) for colorectal cancer (CRC) in males and females aged 18–49 years for individual risk markers and for pairs of risk markers in combination. PPV = positive predictive value. Sally A Stapley et al. Br J Gen Pract doi:10.3399/bjgp17X690425 ©2017 by British Journal of General Practice

PPVs (95% CI) for inflammatory bowel disease (IBD) in males and females aged 18–49 years for individual risk markers and for pairs of risk markers in combination. PPVs (95% CI) for inflammatory bowel disease (IBD) in males and females aged 18–49 years for individual risk markers and for pairs of risk markers in combination. PPV = positive predictive value. Sally A Stapley et al. Br J Gen Pract doi:10.3399/bjgp17X690425 ©2017 by British Journal of General Practice