The clinical spectrum of tubulointerstitial nephritis

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The clinical spectrum of tubulointerstitial nephritis Asghar Rastegar, Michael Kashgarian Kidney International Volume 54, Issue 2, Pages 313-327 (August 1998) DOI: 10.1046/j.1523-1755.1998.00001.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 (A) Low power view of the cortex of the kidney of a patient who died of renal failure secondary to analgesic induced tubulointerstitial nephritis. There is extensive interstitial scarring (represented by the green staining of collagen) and tubular atrophy with no significant cellular infiltrate. This cortical change was associated with medullary scars secondary to papillary necrosis (original magnification ×50 Masson trichrome). (B) Low power view of a renal biopsy of a patient with renal sarcoidosis. The interstitium contains several confluent non caseating granulomata (arrowhead) and a nonspecific mononuclear infiltrate (original magnification ×100, hematoxylin and eosin stain). (C) High power view of the interstitial infiltrate of a renal biopsy of a patient with acute allergic interstitial nephritis secondary to ingestion of a nonsteroidal anti inflammatory drug. There is interstitial edema and a mixed cellular infiltrate which contains mononuclear cells, polymorhonuclear leukocytes and eosinophils (arrowheads). There is also evidence of tubulitis (tubule identified by T) with foci of individual tubular epithelial cell necrosis (original magnification ×300, hematoxylin and eosin stain). (D) Electron micrograph of the nucleus of a proximal tubular epithelial cell of a patient with lead nephropathy. There is an electron dense intranuclear inclusion (arrowhead) that probably represents a lead metallothionein complex. These inclusions are characteristic of lead toxicity but are not uniformly present in patients with lead nephropathy, especially in advanced disease (original magnification ×13,600). Kidney International 1998 54, 313-327DOI: (10.1046/j.1523-1755.1998.00001.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 313-327DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 313-327DOI: (10.1046/j.1523-1755.1998.00001.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 313-327DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 313-327DOI: (10.1046/j.1523-1755.1998.00001.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 313-327DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 313-327DOI: (10.1046/j.1523-1755.1998.00001.x) Copyright © 1998 International Society of Nephrology Terms and Conditions