OR (95% CI) for CHD associated with inflammatory markers in all participants and in subsets of non-users of statins or non-users of aspirin therapy. OR (95% CI) for CHD associated with inflammatory markers in all participants and in subsets of non-users of statins or non-users of aspirin therapy. The ORs are the associations of inflammatory markers with CHD in the top relative to the bottom third in controls in all participants and in subsets who were non-users of statins or non-users of aspirin therapy. All analyses were adjusted for age, sex, country, smoking status, history of hypertension, diabetes status and plasma lipid levels and body mass index. Symbols and conventions as in figure 1. CHD, coronary heart disease; CRP, C reactive protein; IFN-γ, interferon-gamma; IL, interleukin; IL-6R, IL-6 receptor; TNF-α, tumour necrosis factor-alpha. Robert Clarke et al. Open Heart 2018;5:e000807 ©2018 by British Cardiovascular Society