Update on epigenetics in allergic disease

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Presentation transcript:

Update on epigenetics in allergic disease Hani Harb, MSc, Harald Renz, MD Journal of Allergy and Clinical Immunology Volume 135, Issue 1, Pages 15-24 (January 2015) DOI: 10.1016/j.jaci.2014.11.009 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Histone modifications. The illustration shows both histone acetylation and histone methylation and the different modifications on lysine residues with regard to histone methylation causing either opening of the chromatin or closure. AC, Acetylation; K, lysine residue where the acetyl or methyl group is attached; ME, methylation. Journal of Allergy and Clinical Immunology 2015 135, 15-24DOI: (10.1016/j.jaci.2014.11.009) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Yin and yang of both gene activation and gene silencing. Different epigenetic modifications and their enzymatic machinery. Journal of Allergy and Clinical Immunology 2015 135, 15-24DOI: (10.1016/j.jaci.2014.11.009) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions