Fig. 5. MMP-7 expression in human liver, EHBD, and gallbladder.

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Fig. 5. MMP-7 expression in human liver, EHBD, and gallbladder. MMP-7 expression in human liver, EHBD, and gallbladder. (A) Immunohistochemical staining of normal human liver shows minimal or no expression of MMP-7 in hepatocytes and IHBDs but intense expression in the biliary epithelium of gallbladder (GB) and EHBD. Scale bars, 50 μm (in liver, GB, and EHBD) and 20 μm (in IHBD). (B) Variable intensity of expression (0 to 3+) of MMP-7 in the cytoplasm of intrahepatic biliary epithelium of BA subjects. (C) Livers of patients with α1-antitrypsin deficiency had lower MMP-7 expression in the IHBDs. Scale bar, 20 μm for both (B) and (C). (D) Percentage of livers showing different intensities of MMP-7 immunostaining in patients with BA and α1-antitrypsin (A1AT) deficiency. (E) Hepatic mRNA expression of MMP-7 for BA (n = 64), IHC (n = 14), and NC (n = 7). Expression is normalized to NCs and presented as fold change. P values are from Kruskal-Wallis test. Chatmanee Lertudomphonwanit et al., Sci Transl Med 2017;9:eaan8462 Published by AAAS