Sandra E. Kleiman, Ph. D. , Batia Bar-Shira Maymon, Ph. D

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Histone H4 acetylation and AZFc involvement in germ cells of specimens of impaired spermatogenesis Sandra E. Kleiman, Ph.D., Batia Bar-Shira Maymon, Ph.D., Ron Hauser, M.D., Amnon Botchan, M.D., Gedalia Paz, Ph.D., Haim Yavetz, M.D., Leah Yogev, Ph.D. Fertility and Sterility Volume 89, Issue 6, Pages 1728-1736 (June 2008) DOI: 10.1016/j.fertnstert.2007.05.068 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A)Western blotting detection of Hypac-H4 and Lys12ac-H4 in testicular biopsies of complete spermatogenesis (group A), and mixed atrophy with AZFc deleted (group C) specimens. (B) Immunohistochemical identification of Hypac-H4 and Lys12ac-H4 in testicular specimens from groups A, B, and C. Spermatid is indicated by an arrow; spermatogonia is indicated by an arrowhead. Fertility and Sterility 2008 89, 1728-1736DOI: (10.1016/j.fertnstert.2007.05.068) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Differences in the percentage of cells with Hypac-H4 and Lys12ac-H4 in specimens with complete spermatogenesis (group A) and in both groups of mixed atrophy (group B and C) by box and whisker plot. The box encloses the middle half of the data (supplying the first and third quartiles) and bisected by the median value. The vertical lines at the top and bottom of the box indicate the range of “typical” data values. Extreme values are displayed as asterisks; a, statistically significant difference between group A and groups B and C in percentage of spermatogonia with Hypac-H4 and Lys12ac-H4 (Kruskal-Wallis, P=.0073 and P=.039, respectively); b, statistically significant difference between groups A and B in percentage of elongating spermatids with Hypac-H4 (Kruskal-Wallis, P=.034). Fertility and Sterility 2008 89, 1728-1736DOI: (10.1016/j.fertnstert.2007.05.068) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions