Volume 386, Issue 10001, Pages (October 2015)

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Volume 386, Issue 10001, Pages 1353-1361 (October 2015) Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials The Lancet Volume 386, Issue 10001, Pages 1353-1361 (October 2015) DOI: 10.1016/S0140-6736(15)60908-4 Copyright © 2015 Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Recurrence by site and breast cancer mortality in 24 trials of bisphosphonate versus no bisphosphonate (control) Kaplan-Meier graphs showing effects of treatment allocation on 10-year outcomes in all 18 766 patients. (A) Any recurrence. (B) Distant recurrence. (C) Bone recurrence. (D) Breast cancer mortality. O–E=observed minus expected. V=variance of O–E. RR=rate ratio (exp[{O–E}/V]). Error bars are SE. The Lancet 2015 386, 1353-1361DOI: (10.1016/S0140-6736(15)60908-4) Copyright © 2015 Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Multiple subgroup analyses of effects on bone recurrence in trials of bisphosphonate versus no bisphosphonate (control) Results are plotted as black squares with horizontal lines that denote 99% rather than 95% CIs to allow for multiple hypothesis testing. Total is plotted as a white diamond that denotes 95% CI. ER=oestrogen receptor. O–E=observed minus expected. The Lancet 2015 386, 1353-1361DOI: (10.1016/S0140-6736(15)60908-4) Copyright © 2015 Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Main outcomes in premenopausal (excluding perimenopausal) and in postmenopausal women in trials of bisphosphonate versus no bisphosphonate (control) Kaplan-Meier graphs showing the effects of treatment allocation on 10-year breast cancer outcomes. (A) Premenopausal and (B) postmenopausal bone recurrence. (C) Premenopausal and (D) postmenopausal distant recurrence outside the bone. (E) Premenopausal and (F) postmenopausal breast cancer mortality. O-E=observed minus expected. V=variance of O–E. RR=rate ratio (exp[{O–E}/V]). Error bars are SE. The Lancet 2015 386, 1353-1361DOI: (10.1016/S0140-6736(15)60908-4) Copyright © 2015 Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Open Access article distributed under the terms of CC BY Terms and Conditions