Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early.

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Presentation transcript:

Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix K.A Elsaid, M.S., G.D Jay, M.D., Ph.D., C.O Chichester, Ph.D. Osteoarthritis and Cartilage Volume 11, Issue 9, Pages 673-680 (September 2003) DOI: 10.1016/S1063-4584(03)00151-1

Fig. 1 Collagen type II (CII) peptides concentrations in SF from patients with KJS, OA and RA using a sandwich ELISA. ∗ CII peptides concentrations in KJS were significantly higher (P<0.001) than both OA and RA aspirates. ∗∗ CII peptides concentrations in RA were significantly higher (P<0.001) than OA aspirates. Osteoarthritis and Cartilage 2003 11, 673-680DOI: (10.1016/S1063-4584(03)00151-1)

Fig. 2 Epitope 9A4 concentration by inhibition ELISA in SF from patients with KJS, OA and RA. ∗ Epitope 9A4 concentration in KJS was significantly higher (P=0.012) than OA aspirates. Osteoarthritis and Cartilage 2003 11, 673-680DOI: (10.1016/S1063-4584(03)00151-1)

Fig. 3 Epitope 5-D-4 keratan sulfate concentration by inhibition ELISA in SF from patients with KJS, OA and RA. ∗ 5-D-4 epitope concentration in OA was significantly higher (P<0.05) than KJS aspirates. ∗∗ 5-D-4 epitope concentration in RA was significantly higher (P<0.05) than OA aspirates. Osteoarthritis and Cartilage 2003 11, 673-680DOI: (10.1016/S1063-4584(03)00151-1)

Fig. 4 Elastase activity in SF from patients with KJS, OA and RA using SANA substrate. (a) Elastase activity in SF from patients with KJS, OA and RA. ∗ Elastase activity in KJS was significantly higher (P<0.05) than OA aspirates. ∗∗ Elastase activity in RA was significantly higher (P<0.05) than OA aspirates. (b) Inhibition of elastase activity in KJS, OA and RA SF by EDTA treatment. Osteoarthritis and Cartilage 2003 11, 673-680DOI: (10.1016/S1063-4584(03)00151-1)

Fig. 5 Correlations between elastase activity and collagen type II epitopes concentrations in SF from patients with KJS. (a) Correlation between elastase activity and CII peptides concentrations. r=0.397, P=0.128. (b) Correlation between elastase activity and 9A4 epitope concentration. r=0.583, P=0.008. Osteoarthritis and Cartilage 2003 11, 673-680DOI: (10.1016/S1063-4584(03)00151-1)