Most Individuals With Advanced Cirrhosis Have Sleep Disturbances, Which Are Associated With Poor Quality of Life Marwan Ghabril, Mollie Jackson, Raghavender.

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Most Individuals With Advanced Cirrhosis Have Sleep Disturbances, Which Are Associated With Poor Quality of Life Marwan Ghabril, Mollie Jackson, Raghavender Gotur, Regina Weber, Eric Orman, Raj Vuppalanchi, Naga Chalasani Clinical Gastroenterology and Hepatology Volume 15, Issue 8, Pages 1271-1278.e6 (August 2017) DOI: 10.1016/j.cgh.2017.01.027 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 A box plot describing CLDQ scores (median, bold horizontal line; interquartile range, box; and range, whiskers) in subjects grouped according to category of sleep disturbance including normal, mild, moderate, and severe. Comparisons of CLDQ between all categories were statistically significant, with exception of mild versus moderate sleep disturbance. Clinical Gastroenterology and Hepatology 2017 15, 1271-1278.e6DOI: (10.1016/j.cgh.2017.01.027) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Random forest classification and biochemical importance plot listing the metabolites in order of degree of alteration between patients with no and any sleep disturbance (A) and between patients with no, mild, and severe sleep disturbance (B). Clinical Gastroenterology and Hepatology 2017 15, 1271-1278.e6DOI: (10.1016/j.cgh.2017.01.027) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 (A) Actiwatch 2; Phillips Healthcare (Andover MA) actigraphy wrist device and a sample 5-day data recording (B). Clinical Gastroenterology and Hepatology 2017 15, 1271-1278.e6DOI: (10.1016/j.cgh.2017.01.027) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 2 A box plot describing CLDQ (median, bold horizontal line; interquartile range, box; and range, whiskers) in 69 subjects without OSA, RLS, muscle cramps, or opiate therapy and grouped according to sleep disturbance categories of normal (PSQI 0–5), mild (PSQI 6–8), moderate (PSQI 9–11), and severe (PSQI >11). Analysis of variance was significant, P < 10–5. Comparisons of CLDQ between all categories were statistically significant, with exception of mild versus moderate sleep disturbance. Daytime somnolence was increased in 24%, 13%, 38%, and 53%, respectively; P = .07. Clinical Gastroenterology and Hepatology 2017 15, 1271-1278.e6DOI: (10.1016/j.cgh.2017.01.027) Copyright © 2017 AGA Institute Terms and Conditions