Effect of prophylactic 5-HT3 receptor antagonists on pruritus induced by neuraxial opioids: a quantitative systematic review† M.-P. Bonnet, E. Marret,

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Presentation transcript:

Effect of prophylactic 5-HT3 receptor antagonists on pruritus induced by neuraxial opioids: a quantitative systematic review† M.-P. Bonnet, E. Marret, J. Josserand, F.J. Mercier British Journal of Anaesthesia Volume 101, Issue 3, Pages 311-319 (September 2008) DOI: 10.1093/bja/aen202 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Flow chart of systematic research. British Journal of Anaesthesia 2008 101, 311-319DOI: (10.1093/bja/aen202) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Effect of 5-HT3 antagonists on the risk of pruritus after administration of spinal or epidural opioids (OR, odds ratio). British Journal of Anaesthesia 2008 101, 311-319DOI: (10.1093/bja/aen202) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 L'Abbé plot of the risk of pruritus for 5-HT3 antagonists vs placebo. Closed circles, incidence of pruritus was significantly (P<0.05) lower in the 5-HT3 antagonist group; open circles, no significant difference in the 5-HT3 antagonist group compared with the placebo group. British Journal of Anaesthesia 2008 101, 311-319DOI: (10.1093/bja/aen202) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Effect of 5-HT3 antagonists on the risk of pruritus after administration of spinal or epidural opioids in patients undergoing Caesarean section (OR, odds ratio). British Journal of Anaesthesia 2008 101, 311-319DOI: (10.1093/bja/aen202) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 5 Funnel plot with 95% CI for all trials investigating the incidence of pruritus in patients receiving neuraxial opioids and undergoing all surgical procedures and labour (OR, odds ratio). British Journal of Anaesthesia 2008 101, 311-319DOI: (10.1093/bja/aen202) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 6 Effect of 5-HT3 antagonists on the pruritus intensity score after administration of neuraxial opioids (WMD, weighted mean difference). British Journal of Anaesthesia 2008 101, 311-319DOI: (10.1093/bja/aen202) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 7 Effect of 5-HT3 antagonists on the treatment request for pruritus after administration of neuraxial opioids (OR, odds ratio). British Journal of Anaesthesia 2008 101, 311-319DOI: (10.1093/bja/aen202) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions