Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis Pedro R. Moreno, MD, Luis Astudillo, MD, Sammy.

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Presentation transcript:

Increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis Pedro R. Moreno, MD, Luis Astudillo, MD, Sammy Elmariah, MD, MPH, K. Raman Purushothaman, MD, Meeranani Purushothaman, PhD, Patrick A. Lento, MD, Samin K. Sharma, MD, Valentin Fuster, MD, PhD, David H. Adams, MD The Journal of Thoracic and Cardiovascular Surgery Volume 142, Issue 4, Pages 895-901 (October 2011) DOI: 10.1016/j.jtcvs.2011.03.002 Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Immunohistochemical staining of severely stenotic bicuspid and tricuspid aortic valves. Macrophages and T lymphocytes were stained with anti-CD68/CD3 monoclonal antibodies conjugated to a red chromogen (red arrows). Neovessels were selectively stained with a monoclonal antibody to the endothelial cell marker CD34 conjugated with a blue chromogen (blue arrows). More inflammatory cell infiltration and neovascularization is noted in bicuspid (A and B) compared with tricuspid (C and D) valves. The aortic side of the aortic valve is depicted. The Journal of Thoracic and Cardiovascular Surgery 2011 142, 895-901DOI: (10.1016/j.jtcvs.2011.03.002) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Inflammation and neovascularization in bicuspid and tricuspid aortic valve specimens. A, The mean density of inflammatory cells (cells per square millimeter) noted in bicuspid aortic valves was significantly greater than that seen in tricuspid valves (P = .002). B, The mean density of neovessels (vessels per square millimeter) was also significantly greater in bicuspid aortic valves compared with that seen in tricuspid valves (P = .0005). Error bars denote standard deviations. C, Gene expression of chondromodulin 1, a potent antiangiogenic factor, is significantly downregulated in congenital bicuspid aortic valves compared with that seen in tricuspid aortic valves (P = .0003). D, However, expression of vascular endothelial growth factor (VEFG), which is proangiogenic, was upregulated in congenital bicuspid aortic valves (P = .02). The Journal of Thoracic and Cardiovascular Surgery 2011 142, 895-901DOI: (10.1016/j.jtcvs.2011.03.002) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions