Geometric mean concentration-time profiles of (A) racemic BUP, R-BUP, and S-BUP; (B) racemic OHBUP, RR-OHBUP, and SS-OHBUP; (C) racemic ERY, SR-ERYHBUP,

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Geometric mean concentration-time profiles of (A) racemic BUP, R-BUP, and S-BUP; (B) racemic OHBUP, RR-OHBUP, and SS-OHBUP; (C) racemic ERY, SR-ERYHBUP, and RS-ERYHBUP; and (D) THR, RR-THRHBUP, and SS-THRHBUP in 15 healthy volunteers after a single 100-mg oral dose of racemic BUP. Symbols and error bars denote observed geometric means and limits of the 95% confidence interval, respectively. Geometric mean concentration-time profiles of (A) racemic BUP, R-BUP, and S-BUP; (B) racemic OHBUP, RR-OHBUP, and SS-OHBUP; (C) racemic ERY, SR-ERYHBUP, and RS-ERYHBUP; and (D) THR, RR-THRHBUP, and SS-THRHBUP in 15 healthy volunteers after a single 100-mg oral dose of racemic BUP. Symbols and error bars denote observed geometric means and limits of the 95% confidence interval, respectively. Andrea R. Masters et al. J Pharmacol Exp Ther 2016;358:230-238 Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics