Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women

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Presentation transcript:

Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women Jeremy M. Groll, M.D., Rebecca S. Usadi, M.D., Bruce A. Lessey, M.D., Ph.D., Ruth Lininger, M.D., Steven L. Young, M.D., Ph.D., Marc A. Fritz, M.D. Fertility and Sterility Volume 92, Issue 6, Pages 2058-2061 (December 2009) DOI: 10.1016/j.fertnstert.2009.06.018 Copyright © 2009 Terms and Conditions

Figure 1 (A) Photomicrographs showing immunohistochemical localization of two biomarkers of receptivity in endometrium from normal and study women. β3 integrin subunit (β3) and osteopontin (OPN) are strongly expressed in the receptive midluteal phase as well as in all study conditions. Original magnification, 20×. (B) H-scores of immunohistochemcial stains. ML not different than study samples for β3 and OPN; (C) Immunoblots for β3, OPN, and ER-α. Note strong expression of β3 and OPN in the normal midluteal samples as well as in the altered hormonal conditions. EL: early luteal, ML: midluteal, LL: late luteal, LowE: subphysiologic estrogen, PhysE: physiologic estrogen, HighE: supraphysiologic estrogen. Fertility and Sterility 2009 92, 2058-2061DOI: (10.1016/j.fertnstert.2009.06.018) Copyright © 2009 Terms and Conditions