Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men Viktor Meineke, M.D.,

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Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men Viktor Meineke, M.D., Monica B Frungieri, Ph.D., Berthold Jessberger, M.D., Ph.D., Hermann-Josef Vogt, M.D., Artur Mayerhofer, M.D. Fertility and Sterility Volume 74, Issue 2, Pages 239-244 (August 2000) DOI: 10.1016/S0015-0282(00)00626-9

Figure 1 Tryptase-immunoreactive mast cells in the human testis. (A), Immunoreactive mast cell (arrow) in a testis with normal spermatogenesis is seen in the interstitial compartment. T = seminiferous tubule; bar = 40 μm. (B), Several interstitial (arrows) and peritubular mast cells (asterisks) are seen in the testis of a patient with germ cell arrest syndrome. Bar = 40 μm. Meineke. Tryptase in testicular mast cells. Fertil Steril 2000. Fertility and Sterility 2000 74, 239-244DOI: (10.1016/S0015-0282(00)00626-9)

Figure 2 Evaluation of immunostained mast cells. Results were obtained in parallel in the same sections and are expressed as mast cells per tubule and mast cells per mm2 in normal, germ cell arrest syndrome (GA), and Sertoli-cell–only syndrome (SCO) biopsies. The letters over the columns indicate statistically significant differences between the groups (Student-Newman-Keuls test). Meineke. Tryptase in testicular mast cells. Fertil Steril 2000. Fertility and Sterility 2000 74, 239-244DOI: (10.1016/S0015-0282(00)00626-9)

Figure 3 Transmission electron micrographs. (A), A typical rounded interstitial mast cell with characteristic electron-dense granules. Note the adjacent Leydig cells (LC). Bar = 2 μm. (B), An interstitial mast cell in a testis with germ cell arrest syndrome shows only a few granules (arrows). Bar = 1.2 μm. (C), A flattened mast cell with several granules (arrows) is seen in the wall of a seminiferous tubule in a specimen with germ cell arrest syndrome. SC = Sertoli cell; bar = 2 μm. Meineke. Tryptase in testicular mast cells. Fertil Steril 2000. Fertility and Sterility 2000 74, 239-244DOI: (10.1016/S0015-0282(00)00626-9)