Γ-Aminobutyric acid (GABA) a and b receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone

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Presentation transcript:

γ-Aminobutyric acid (GABA) a and b receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone Aldo E Calogero, M.D., Nunziatina Burrello, Ph.D., Emanuela Ferrara, M.D., Jenny Hall, Ph.D., Simon Fishel, Ph.D., Rosario D’Agata, M.D. Fertility and Sterility Volume 71, Issue 5, Pages 930-936 (May 1999) DOI: 10.1016/S0015-0282(99)00063-1

FIGURE 1 Effects of γ-aminobutyric acid (GABA) on the acrosome reaction of human spermatozoa obtained from 10 normozoospermic subjects. ∗P<.05 (vs. 0); †P<.05 (vs. GABA 1 μM); ‡P<.05 (vs. GABA 10 μM). Fertility and Sterility 1999 71, 930-936DOI: (10.1016/S0015-0282(99)00063-1)

FIGURE 2 Effects of bicuculline (BICU) (n = 12), a GABAA receptor antagonist (upper panel), or saclofen (SACL) (n = 9), a GABAB receptor antagonist (lower panel), on the spontaneous acrosome reaction of human spermatozoa and in response to 10 μM of γ-aminobutyric acid (GABA). ∗P<.05 (vs. no-treatment control); †P<.05 (vs. GABA 10 μM). Fertility and Sterility 1999 71, 930-936DOI: (10.1016/S0015-0282(99)00063-1)

FIGURE 3 Effects of increasing concentrations of progesterone on the acrosome reaction of human spermatozoa obtained from eight normozoospermic subjects. ∗P<.05 (vs. 0); †P<.05 (vs. progesterone 10 μM); ‡P<.05 (vs. progesterone 30 μM). Fertility and Sterility 1999 71, 930-936DOI: (10.1016/S0015-0282(99)00063-1)

FIGURE 4 Effects of the GABAA receptor antagonist bicuculline (BICU) on the progesterone (Prog)–stimulated acrosome reaction of human spermatozoa obtained from 10 normozoospermic subjects. ∗P<.05 (vs. 0); †P<.05 (vs. progesterone alone). Fertility and Sterility 1999 71, 930-936DOI: (10.1016/S0015-0282(99)00063-1)