Pharmacokinetics of tissue plasminogen activator in an isolated extracorporeal circuit Bruno Geier, MD, Marcus Großefeld, MD, Letterio Barbera, MD, Achim.

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Presentation transcript:

Pharmacokinetics of tissue plasminogen activator in an isolated extracorporeal circuit Bruno Geier, MD, Marcus Großefeld, MD, Letterio Barbera, MD, Achim Mumme, MD Journal of Vascular Surgery Volume 33, Issue 1, Pages 165-169 (January 2001) DOI: 10.1067/mva.2001.109765 Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Diagram of heart-lung machine and cannulation sites in groin. Journal of Vascular Surgery 2001 33, 165-169DOI: (10.1067/mva.2001.109765) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Relation between levels of tPA in central venous blood and in perfusion solution. Relative concentration of tPA in systemic blood was calculated as tPA levels in central venous blood divided by respective tPA levels in perfusion solution times 100. It increased during perfusion and after 60 minutes reached 1.4% of concentration in perfusion solution. tPA, Tissue plasminogen activator. Journal of Vascular Surgery 2001 33, 165-169DOI: (10.1067/mva.2001.109765) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions