Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis.

Slides:

Advertisements

Similar presentations

Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.

Advertisements

B. Bai, Y. Li Osteoarthritis and Cartilage

Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis L. Lugo, A. Villalvilla, R. Gómez, M. Bellido,

The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior.

Nociceptive phenotype alterations of dorsal root ganglia neurons innervating the subchondral bone in osteoarthritic rat knee joints K. Aso, M. Izumi,

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits E. Calvo, M.D., S. Castañeda, M.D., R.

Efficacy of patient education and supervised exercise vs patient education alone in patients with hip osteoarthritis: a single blind randomized clinical.

Nociceptive phenotype alterations of dorsal root ganglia neurons innervating the subchondral bone in osteoarthritic rat knee joints K. Aso, M. Izumi,

H.J. Smith, Ph.D., J.B. Richardson, M.D., A. Tennant, Ph.D.

Definition of a Critical Size Osteochondral Knee Defect and its Negative Effect on the Surrounding Articular Cartilage in the Rat H. Katagiri, L.F. Mendes,

Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes

Extracorporeal shock wave therapy improves motor dysfunction and pain originating from knee osteoarthritis in rats N. Ochiai, M.D., Ph.D., S. Ohtori,

R.E. Fransès, D.F. McWilliams, P.I. Mapp, D.A. Walsh

An in vivo cross-linkable hyaluronan gel with inherent anti-inflammatory properties reduces OA cartilage destruction in female mice subjected to cruciate.

Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis L. Lugo, A. Villalvilla, R. Gómez, M. Bellido,

B.J. Ahern, J. Parvizi, R. Boston, T.P. Schaer

Aging-related inflammation in osteoarthritis

B.J. Ahern, J. Parvizi, R. Boston, T.P. Schaer

Osteoarthritis as a disease of mechanics

Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats A.G.H. Mierzwa,

Decrease in oxidative stress and histological changes induced by physical exercise calibrated in rats with osteoarthritis induced by monosodium iodoacetate

Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture.

PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage S. Otsuka, M.D., T. Aoyama, M.D., Ph.D.,

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

Injury of primary afferent neurons may contribute to osteoarthritis induced pain: an experimental study using the collagenase model in rats S. Adães,

Effects of exercise vs experimental osteoarthritis on imaging outcomes

The use of hyperosmotic saline for chondroprotection: implications for orthopaedic surgery and cartilage repair N.M. Eltawil, S.E.M. Howie, A.H.R.W.

Metabolic Dysregulation Accelerates Progression in Early Degenerative Rat Knee Joints Driven by Local Inflammatory Changes H.M. de Visser, S.C. Mastbergen,

Pre-operative interventions (non-surgical and non-pharmacological) for patients with hip or knee osteoarthritis awaiting joint replacement surgery – a.

Intra-articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception: association with attenuation of N-methyl-d-aspartate (NMDA)

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Destabilization of the medial meniscus leads to subchondral bone defects and site- specific cartilage degeneration in an experimental rat model H. Iijima,

Transdermal buprenorphine plus oral paracetamol vs an oral codeine-paracetamol combination for osteoarthritis of hip and/or knee: a randomised trial

Exercise intervention increases expression of bone morphogenetic proteins and prevents the progression of cartilage-subchondral bone lesions in a post-traumatic.

B. F. Riecke, R. Christensen, S. Torp-Pedersen, M. Boesen, H

M. A. McNulty, R. F. Loeser, C. Davey, M. F. Callahan, C. M

Joint distraction attenuates osteoarthritis by reducing secondary inflammation, cartilage degeneration and subchondral bone aberrant change Y. Chen,

A.C. Dang, M.D., A.P. Warren, M.D., H.T. Kim, M.D., Ph.D.

The role of subchondral bone resorption pits in osteoarthritis: MMP production by cells derived from bone marrow A. Shibakawa, M.D., Ph.D., K. Yudoh,

Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis L. Habouri, F.E. El Mansouri, Y.

Lentiviral vector-mediated shRNAs targeting a functional isoform of the leptin receptor (Ob-Rb) inhibit cartilage degeneration in a rat model of osteoarthritis

The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study G. Tardif, Ph.D., J.-P. Pelletier,

Stem cell therapy for human cartilage defects: a systematic review

J. Ranstam Osteoarthritis and Cartilage

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the dog J.L. Cook, K. Kuroki, D. Visco, J.-P.

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis M. Bellido, L. Lugo,

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis S. Thysen, F.P. Luyten, R.J. Lories Osteoarthritis.

An experimental study on costal osteochondral graft

Osteoarthritis development in novel experimental mouse models induced by knee joint instability S. Kamekura, M.D., K. Hoshi, M.D., Ph.D., T. Shimoaka,

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis M. Blagojevic, C. Jinks, A. Jeffery, K.P.

The effects of alendronate in the treatment of experimental osteonecrosis of the hip in adult rabbits J.G. Hofstaetter, M.D., J. Wang, M.D., Ph.D., J.

A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading H.E. Kloefkorn, B.Y. Jacobs,

Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing.

Who should have a joint replacement? A plea for more ‘phronesis’

Effects of low level laser therapy: a study of status of cartilage, subchondral bone and gait adaptation in the rat anterior cruciate ligament transection.

D.J. Hunter Osteoarthritis and Cartilage

Definition of a Critical Size Osteochondral Knee Defect and its Negative Effect on the Surrounding Articular Cartilage in the Rat H. Katagiri, L.F. Mendes,

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse S.S. Glasson, M.G. Chambers, W.B. Van.

P. Rahnamay Moshtagh, N. M. Korthagen, S. G. Plomp, B. Pouran, A

C. Ratzlaff, M. Koehoorn, J. Cibere, J. Kopec

A. Sophocleous, A.E. Börjesson, D.M. Salter, S.H. Ralston

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

Osteoarthritis year 2012 in review: biology

Osteoarthritis year in review 2015: biology

Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis

Effects of helium–neon laser on the mucopolysaccharide induction in experimental osteoarthritic cartilage Y.-S. Lin, M.Sc, Dr M.-H. Huang, M.D., Ph.D.,

Value of tomosynthesis for lesion evaluation of small joints in osteoarthritic hands using the OARSI score K. Martini, A.S. Becker, R. Guggenberger,

General Information Osteoarthritis and Cartilage

Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis

Presentation transcript:

Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats L. Assis, L.P. Milares, T. Almeida, C. Tim, A. Magri, K.R. Fernandes, C. Medalha, A.C. Muniz Renno Osteoarthritis and Cartilage Volume 24, Issue 1, Pages 169-177 (January 2016) DOI: 10.1016/j.joca.2015.07.020 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative photomicrographs of the experimental groups. Organization of chondrocytes (arrow), fibrillation and irregularities (arrowhead), joint cartilage (JC), subchondral bone (b). (A) Control – CG; (B) Osteoarthritis – OAC; (C) Osteoarthritis plus exercise training – OAT; (D) Osteoarthritis plus LLLT – OAL; (E) Osteoarthritis plus exercise training associated with LLLT – OATL. (Stain: H.E.; Scale Bar: 100 μm). Osteoarthritis and Cartilage 2016 24, 169-177DOI: (10.1016/j.joca.2015.07.020) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Histopathological evaluation using OARSI Score: CG – Control; OAC – Osteoarthritis; OAT – Osteoarthritis plus exercise training; OAL – Osteoarthritis plus LLLT; OATL – Osteoarthritis plus exercise training associated with LLLT. (Scale Bar: 50 μm) *P < 0.0001 vs CG; #P < 0.05 vs OAC. Osteoarthritis and Cartilage 2016 24, 169-177DOI: (10.1016/j.joca.2015.07.020) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 (A) Results of the morphometric analysis of cellularity *P = 0.037 vs CG. (B) Results of morphometric analysis of thickness. CG – Control; OAC – Osteoarthritis; OAT – Osteoarthritis plus exercise training; OAL – Osteoarthritis plus LLLT; OATL – Osteoarthritis plus exercise training associated with LLLT. *P < 0.05 vs OAC. Osteoarthritis and Cartilage 2016 24, 169-177DOI: (10.1016/j.joca.2015.07.020) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 (A) Representative sections of IL-1β immunohistochemistry. Immunolabeled chondrocytes (arrow). (A) Control – CG; (B) Osteoarthritis – OAC; (C) Osteoarthritis plus exercise training – OAT; (D) Osteoarthritis plus LLLT – OAL; (E) Osteoarthritis plus exercise training associated with LLLT – OATL. (Scale Bar: 50 μm); (B) Results of semi-quantitative analysis of the IL-1β expression *P < 0.05 vs CG; #P < 0.05 vs OAC. Osteoarthritis and Cartilage 2016 24, 169-177DOI: (10.1016/j.joca.2015.07.020) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 (A) Representative sections of caspase-3 immunohistochemistry. Immunolabeled chondrocytes (arrow). (A) Control – CG; (B) Osteoarthritis – OAC; (C) Osteoarthritis plus exercise training – OAT; (D) Osteoarthritis plus LLLT – OAL; (E) Osteoarthritis plus exercise training associated with LLLT – OATL. (Scale Bar: 50 μm); (B) Results of semi-quantitative analysis of the caspase-3 expression *P < 0.0001 vs CG; #P < 0.05 vs OAC; &P < 0.05 vs OATL. Osteoarthritis and Cartilage 2016 24, 169-177DOI: (10.1016/j.joca.2015.07.020) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 (A) Representative sections of MMP-13 immunohistochemistry. Immunolabeled chondrocytes (arrow). (A) Control – CG; (B) Osteoarthritis – OAC; (C) Osteoarthritis plus exercise training – OAT; (D) Osteoarthritis plus LLLT – OAL; (E) Osteoarthritis plus exercise training associated with LLLT – OATL. (Scale Bar: 50 μm). (B) Results of semi-quantitative analysis of the caspase-3 expression *P < 0.05 vs CG; #P < 0.05 vs OAC. Osteoarthritis and Cartilage 2016 24, 169-177DOI: (10.1016/j.joca.2015.07.020) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions