Anaphylactoid reactions to protamine: An often lethal complication in insulin-dependent diabetic patients undergoing vascular surgery Sushil K. Gupta,

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Presentation transcript:

Anaphylactoid reactions to protamine: An often lethal complication in insulin-dependent diabetic patients undergoing vascular surgery Sushil K. Gupta, MD, Frank J. Veith, MD, Enrico Ascer, MD, Kurt R. Wengerter, MD, Charles Franco, MD, David Amar, MD, El-Sayed El- Gaweet, MD, Asha Gupta, MD Journal of Vascular Surgery Volume 9, Issue 2, Pages 342-350 (February 1989) DOI: 10.1016/0741-5214(89)90055-4 Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 IgE antibodies are bound to the mast cell by a specific receptor. This figure shows cross-linking of IgE antibodies by the antigen causing the release of granules containing mediators. Journal of Vascular Surgery 1989 9, 342-350DOI: (10.1016/0741-5214(89)90055-4) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Antigen-antibody complex activating the classic complement pathway release of C3a and C5a, which are potent anaphylatoxins. Journal of Vascular Surgery 1989 9, 342-350DOI: (10.1016/0741-5214(89)90055-4) Copyright © 1989 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions