Volume 78, Issue 6, Pages 611-618 (September 2010) The peritoneal osmotic conductance is low well before the diagnosis of encapsulating peritoneal sclerosis is made  Mark L. Lambie, Biju John, Lily Mushahar, Christopher Huckvale, Simon J. Davies  Kidney International  Volume 78, Issue 6, Pages 611-618 (September 2010) DOI: 10.1038/ki.2010.186 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Kaplan–Meier plot of encapsulating peritoneal sclerosis (EPS) free survival. The probability of remaining free of EPS with duration of time on peritoneal dialysis (PD). This includes two early cases associated with severe, prolonged peritonitis. The number of patients at risk at the time of each case of EPS is shown at the top. Kidney International 2010 78, 611-618DOI: (10.1038/ki.2010.186) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 2 Change in membrane solute transport with time on peritoneal dialysis (PD). Solute transport is measured as the mean annual dialysate/plasma (D/P) creatinine ratio measured at 4h in standard peritoneal equilibration tests with standard error. The star indicates a difference between groups with P=0.007. Kidney International 2010 78, 611-618DOI: (10.1038/ki.2010.186) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 3 Change in ultrafiltration capacity with time on peritoneal dialysis (PD). The ultrafiltration (UF) capacity is the annual mean measured by a 4h peritoneal equilibration test with 2.27% glucose, including approximately 200ml overfill. Bars represent standard error. The stars indicate a difference between groups with P<0.05, unpaired t-test. Kidney International 2010 78, 611-618DOI: (10.1038/ki.2010.186) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 4 Change in membrane solute transport with change in ultrafiltration. Membrane solute transport and ultrafiltration (UF) are measured as the annual mean of measurements of UF capacity and dialysate/plasma (D/P) creatinine ratio in a 4h peritoneal equilibration test with 2.27% glucose, including approximately 200ml overfill. Bars represent standard error. Kidney International 2010 78, 611-618DOI: (10.1038/ki.2010.186) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 5 Glucose exposure with time on peritoneal dialysis (PD). Glucose exposure is measured as the mean of the total number of grams of glucose in the dialysate used by each patient in that year. Bars represent standard error. The stars indicate a difference between groups with P<0.05, unpaired t-test. Kidney International 2010 78, 611-618DOI: (10.1038/ki.2010.186) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 6 Residual renal function with time on peritoneal dialysis (PD). The residual renal function is measured as the median of the urine volume within each group assessed every 6 months from the start of PD. Kidney International 2010 78, 611-618DOI: (10.1038/ki.2010.186) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 7 Peritoneal protein clearance with time on peritoneal dialysis (PD). Peritoneal protein clearance is measured in ml of plasma per day and the bars represent standard errors. There were no significant differences between the groups when applying mixed linear modeling. Kidney International 2010 78, 611-618DOI: (10.1038/ki.2010.186) Copyright © 2010 International Society of Nephrology Terms and Conditions