Volume 54, Issue 5, Pages (November 1998)

Slides:



Advertisements
Similar presentations
Volume 59, Issue 6, Pages (June 2001)
Advertisements

Volume 65, Issue 1, Pages (January 2004)
Lymphatic vessels develop during tubulointerstitial fibrosis
Volume 64, Issue 6, Pages (December 2003)
Volume 63, Issue 1, Pages (January 2003)
Volume 55, Issue 6, Pages (June 1999)
Persistent rejection of peritubular capillaries and tubules is associated with progressive interstitial fibrosis  Akira Shimizu, Kazuhiko Yamada, David.
Volume 54, Issue 3, Pages (September 1998)
Hypertensive nephrosclerosis in African Americans versus Caucasians
Volume 61, Issue 2, Pages (February 2002)
Volume 61, Issue 2, (February 2002)
Volume 69, Issue 10, Pages (May 2006)
Volume 65, Issue 1, Pages (January 2004)
Volume 68, Issue 5, Pages (November 2005)
Volume 66, Issue 6, Pages (December 2004)
Volume 58, Issue 6, Pages (December 2000)
Sayu Omori, Ryuji Fukuzawa, Mariko Hida, Midori Awazu 
Volume 62, Issue 1, Pages (July 2002)
Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes  Lesley Wassef, Darren J. Kelly, Richard E. Gilbert 
Volume 66, Issue 5, Pages (November 2004)
Volume 67, Issue 1, Pages (January 2005)
Volume 68, Issue 3, Pages (September 2005)
Volume 54, Issue 6, Pages (January 1998)
Volume 59, Issue 5, Pages (May 2001)
Volume 69, Issue 1, Pages (January 2006)
Left ventricular hypertrophy in renal failure
Yang Wang, Yi Ping Wang, Yuet-Ching Tay, David C.H. Harris 
Volume 58, Issue 1, Pages (July 2000)
Volume 63, Issue 5, Pages (May 2003)
Volume 71, Issue 1, Pages (January 2007)
Mohammed S. Razzaque, Ph.D., Takashi Taguchi  Kidney International 
Isotretinoin alleviates renal damage in rat chronic glomerulonephritis
Volume 58, Issue 3, Pages (September 2000)
Volume 63, Issue 2, Pages (February 2003)
Lymphatic vessels develop during tubulointerstitial fibrosis
Volume 73, Issue 11, Pages (June 2008)
M.B. Stokes, A.M. Valeri, G.S. Markowitz, V.D. D'Agati 
Role of CD8+ cells in the progression of murine adriamycin nephropathy
Akira Shimizu, Kazuhiko Yamada, David H. Sachs, Robert B. Colvin 
Volume 68, Issue 4, Pages (October 2005)
Wei-Zhong Ying, Pei-Xuan Wang, Paul W. Sanders  Kidney International 
Volume 59, Issue 3, Pages (March 2001)
Caspase-3 and apoptosis in experimental chronic renal scarring
Volume 75, Issue 1, Pages (January 2009)
Volume 66, Issue 5, Pages (November 2004)
Volume 60, Issue 4, Pages (October 2001)
An unusual cause of acute renal failure
C5b-9 regulates peritubular myofibroblast accumulation in experimental focal segmental glomerulosclerosis  Gopala K. Rangan, Jeffrey W. Pippin, William.
Volume 75, Issue 6, Pages (March 2009)
B. Li, T. Morioka, M. Uchiyama, T. Oite  Kidney International 
Volume 71, Issue 9, Pages (May 2007)
Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis  H.-C. Yang, L.-J. Ma, J. Ma, A.B. Fogo 
Volume 62, Issue 3, Pages (September 2002)
Volume 63, Issue 3, Pages (March 2003)
AIDS, nephrotic-range proteinuria, and renal failure
Robert L. Chevalier, Barbara A. Thornhill, Alice Y. Chang 
Volume 55, Issue 6, Pages (June 1999)
Volume 68, Issue 5, Pages (November 2005)
Contribution of tubular injury to loss of remnant kidney function
Volume 58, Issue 4, Pages (October 2000)
Volume 62, Issue 1, Pages (July 2002)
Inhibition of the renin–angiotensin system: is more better?
Volume 73, Issue 5, Pages (March 2008)
Volume 64, Issue 6, Pages (December 2003)
J. Ma, A. Weisberg, J.P. Griffin, D.E. Vaughan, A.B. Fogo, N.J. Brown 
Volume 61, Issue 6, Pages (June 2002)
Volume 65, Issue 1, Pages (January 2004)
Volume 75, Issue 2, Pages (January 2009)
Alex B. Magil, Kathryn Tinckam  Kidney International 
Dysproteinemia and the Kidney: Core Curriculum 2019
Presentation transcript:

Volume 54, Issue 5, Pages 1510-1519 (November 1998) Mycophenolate mofetil attenuates renal injury in the rat remnant kidney  Clarice Kazue Fujihara, Denise Maria Avancini Costa Malheiros, Roberto Zatz, Irene de Lourdes Noronha  Kidney International  Volume 54, Issue 5, Pages 1510-1519 (November 1998) DOI: 10.1046/j.1523-1755.1998.00138.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Light microscopy 60days after renal ablation. (A) Normal glomeruli and interstitium in a Sham rat. (B) Extensive glomerular sclerotic lesion in a NX rat 60days after ablation, consisting of deposition of a PAS-positive material with occlusion of capillary loops and adhesion to Bowman's capsule. Enlargement and inflammation of the cortical interstitial area, with expansion of the extracellular matrix, tubular collapse and cell infiltration, are also observed. (C) Attenuation of glomerular and interstitial injury in a NX rat treated with MMF (PAS stain in 3-μm-thick section, ×200). Kidney International 1998 54, 1510-1519DOI: (10.1046/j.1523-1755.1998.00138.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 The glomerulosclerosis index (A) and the percent renal cortical area occupied by interstitium (B) in the Sham, NX and NX+MMF Groups 60days after renal ablation. *P < 0.05 versus Sham. †P < 0.05 versus NX. Kidney International 1998 54, 1510-1519DOI: (10.1046/j.1523-1755.1998.00138.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Immunohistochemical demonstration in the renal parenchyma of cells expressing the lymphocyte-specific antigen CD-3 (A through C), PCNA (D through F) and ED-1 (G through I). (A) CD-3-positive cells are rare in Sham. (B) Numerous CD-3-positive cells are seen in the renal interstitium of a rat from Group NX seven days after ablation. (C) Only few CD-3-positive interstitial cells in a rat from Group NX+MMF seven days after ablation. (D) PCNA-positive cells are infrequent in Sham. (E) Intense expression of PCNA, especially in tubules and, to a lesser extent, in the interstitium, in a rat from Group NX seven days after renal ablation. (F) Much less numerous PCNA-positive cells in a rat from Group NX+MMF seven days after renal ablation. (G) Macrophage-specific ED-1 positive cells are rarely seen in Sham. (H) ED-1 positive cells are abundant, especially at the interstitium, 60days after renal ablation. (I) much less frequent ED-1-positive cells in a rat from Group NX+MMF (×400). Kidney International 1998 54, 1510-1519DOI: (10.1046/j.1523-1755.1998.00138.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Renal expression of lymphocyte-specific CD-3 antigen at 7 and 30days after ablation in Sham (▿), NX (•) and NX+MMF (○). Kidney International 1998 54, 1510-1519DOI: (10.1046/j.1523-1755.1998.00138.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Time-dependent renal expression of PCNA (A) and ED-1 (B) in Sham (▿), NX (•) and NX+MMF (○) in glomeruli (top), tubules (middle) and interstitium (bottom). Kidney International 1998 54, 1510-1519DOI: (10.1046/j.1523-1755.1998.00138.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1510-1519DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1510-1519DOI: (10.1046/j.1523-1755.1998.00138.x) Copyright © 1998 International Society of Nephrology Terms and Conditions