Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: Results from the TAG Study Elaine.

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Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: Results from the TAG Study Elaine Fuertes, MSc, Michael Brauer, PhD, Elaina MacIntyre, PhD, Mario Bauer, MD, Tom Bellander, MD, Andrea von Berg, MD, PhD, Dietrich Berdel, MD, PhD, Bert Brunekreef, PhD, Moira Chan-Yeung, MB, Ulrike Gehring, PhD, Olf Herbarth, PhD, Barbara Hoffmann, MD, MPH, Marjan Kerkhof, PhD, Claudia Klümper, DrPH, Sibylle Koletzko, MD, PhD, Anita Kozyrskyj, PhD, Inger Kull, PhD, Joachim Heinrich, PhD, Erik Melén, MD, PhD, Göran Pershagen, MD, PhD, Dirkje Postma, PhD, Carla M.T. Tiesler, MSc, Chris Carlsten, MD, MPH Journal of Allergy and Clinical Immunology Volume 132, Issue 2, Pages 342-352.e2 (August 2013) DOI: 10.1016/j.jaci.2013.03.007 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Distribution of air pollutants pooled and by cohort. The interquartile range is indicated by each box height and median level by each dark line. The number of children with health data that also had available air pollution data are given along the top of each graph. NA, Not available. Journal of Allergy and Clinical Immunology 2013 132, 342-352.e2DOI: (10.1016/j.jaci.2013.03.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Associations between allergic rhinitis (stars) and aeroallergen sensitization (dark squares) and NO2, ozone, PM2.5 mass, and PM2.5 absorbance. Models were adjusted for city/center, cohort, sex, birth weight, parental history of atopic disease, maternal smoking during pregnancy, exposure to environmental tobacco smoke at the time of follow-up, maternal age at birth, and intervention status (when applicable). NA, Not available. Journal of Allergy and Clinical Immunology 2013 132, 342-352.e2DOI: (10.1016/j.jaci.2013.03.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Associations between allergic rhinitis (stars) and aeroallergen sensitization (dark squares) and single nucleotide polymorphisms. Po, Pooled; B, BAMSE; C, CAPPS; M, Munich; W/L, Wesel and Leipzig; S, SAGE; and P, PIAMA. The upper confidence limit in SAGE for rs1927911 and allergic rhinitis is 7.44. Models were adjusted for city/center, cohort, sex, birth weight, parental history of atopic disease, maternal smoking during pregnancy, exposure to environmental tobacco smoke at the time of follow-up, maternal age at birth, and intervention status (when applicable). NA, Not available. Journal of Allergy and Clinical Immunology 2013 132, 342-352.e2DOI: (10.1016/j.jaci.2013.03.007) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions