Volume 393, Issue 10170, Pages 407-415 (February 2019) Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials  Jane Armitage, Colin Baigent, Elizabeth Barnes, D John Betteridge, Lisa Blackwell, Michael Blazing, Louise Bowman, Eugene Braunwald, Robert Byington, Christopher Cannon, Michael Clearfield, Helen Colhoun, Rory Collins, Björn Dahlöf, Kelly Davies, Barry Davis, James de Lemos, John R Downs, Paul Durrington, Jonathan Emberson, Bengt Fellström, Marcus Flather, Ian Ford, Maria Grazia Franzosi, Jordan Fulcher, John Fuller, Curt Furberg, David Gordon, Shinya Goto, Antonio Gotto, Heather Halls, Charlie Harper, C Morton Hawkins, Will Herrington, Graham Hitman, Hallvard Holdaas, Lisa Holland, Alan Jardine, J Wouter Jukema, John Kastelein, Sharon Kean, Anthony Keech, Adrienne Kirby, John Kjekshus, Genell Knatterud (deceased), Robert Knopp (deceased), Wolfgang Koenig, Michael Koren, Vera Krane, Martin J Landray, John LaRosa, Eva Lonn, Peter MacFarlane, Stephen MacMahon, Aldo Maggioni, Roberto Marchioli, Ian Marschner, Borislava Mihaylova, Lemuel Moyé, Sabina Murphy, Haruo Nakamura, Andrew Neil, Connie Newman, Rachel O'Connell, Chris Packard, Sarah Parish, Terje Pedersen, Richard Peto, Marc Pfeffer, Neil Poulter, David Preiss, Christina Reith, Paul Ridker, Michele Robertson, Frank Sacks, Naveed Sattar, Roland Schmieder, Patrick Serruys, Peter Sever, John Shaw, Charles Shear, John Simes, Peter Sleight, Enti Spata, Luigi Tavazzi, Jonathan Tobert, Gianni Tognoni, Andrew Tonkin, Stella Trompet, John Varigos, Christoph Wanner, Hans Wedel, Harvey White, John Wikstrand, Lars Wilhelmsen, Kate Wilson, Robin Young, Salim Yusuf, Faiez Zannad Jane Armitage, Colin Baigent, Elizabeth Barnes, D John Betteridge, Lisa Blackwell, Michael Blazing, Louise Bowman, Eugene Braunwald, Robert Byington, Christopher Cannon, Michael Clearfield, Helen Colhoun, Rory Collins, Björn Dahlöf, Kelly Davies, Barry Davis, James de Lemos, John R Downs, Paul Durrington, Jonathan Emberson, Bengt Fellström, Marcus Flather, Ian Ford, Maria Grazia Franzosi, Jordan Fulcher, John Fuller, Curt Furberg, David Gordon, Shinya Goto, Antonio Gotto, Heather Halls, Charlie Harper, C Morton Hawkins, Will Herrington, Graham Hitman, Hallvard Holdaas, Lisa Holland, Alan Jardine, J Wouter Jukema, John Kastelein, Sharon Kean, Anthony Keech, Adrienne Kirby, John Kjekshus, Genell Knatterud (deceased), Robert Knopp (deceased), Wolfgang Koenig, Michael Koren, Vera Krane, Martin J Landray, John LaRosa, Eva Lonn, Peter MacFarlane, Stephen MacMahon, Aldo Maggioni, Roberto Marchioli, Ian Marschner, Borislava Mihaylova, Lemuel Moyé, Sabina Murphy, Haruo Nakamura, Andrew Neil, Connie Newman, Rachel O'Connell, Chris Packard, Sarah Parish, Terje Pedersen, Richard Peto, Marc Pfeffer, Neil Poulter, David Preiss, Christina Reith, Paul Ridker, Michele Robertson, Frank Sacks, Naveed Sattar, Roland Schmieder, Patrick Serruys, Peter Sever, John Shaw, Charles Shear, John Simes, Peter Sleight, Enti Spata, Luigi Tavazzi, Jonathan Tobert, Gianni Tognoni, Andrew Tonkin, Stella Trompet, John Varigos, Christoph Wanner, Hans Wedel, Harvey White, John Wikstrand, Lars Wilhelmsen, Kate Wilson, Robin Young, Salim Yusuf, Faiez Zannad  The Lancet  Volume 393, Issue 10170, Pages 407-415 (February 2019) DOI: 10.1016/S0140-6736(18)31942-1 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 1 Effects on major vascular events per mmol/L reduction in LDL cholesterol by age at randomisation All studies (A) and excluding four trials that exclusively included patients with heart failure or on dialysis (B). Data from participants with missing baseline data included in the totals. RR=rate ratio. The Lancet 2019 393, 407-415DOI: (10.1016/S0140-6736(18)31942-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 2 Effects on major vascular events per mmol/L reduction in LDL cholesterol, subdivided by age at randomisation and particular trial populations Data from participants with missing baseline data included in the totals. RR=rate ratio. The Lancet 2019 393, 407-415DOI: (10.1016/S0140-6736(18)31942-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 3 Effects on components of major vascular events per mmol/L reduction in LDL cholesterol in all studies, by age at randomisation Data from participants with missing baseline data included in the totals. RR=rate ratio. The Lancet 2019 393, 407-415DOI: (10.1016/S0140-6736(18)31942-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 4 Effects on major vascular events per mmol/L reduction in LDL cholesterol, subdivided by age at randomisation and by previous vascular disease Data from participants with missing baseline data included in the totals. RR=rate ratio. The Lancet 2019 393, 407-415DOI: (10.1016/S0140-6736(18)31942-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 5 Effects on vascular death per mmol/L reduction in LDL cholesterol, subdivided by age at randomisation All studies (A) and excluding four trials that exclusively included patients with heart failure or on dialysis (B). Data from participants with missing baseline data included in the totals. RR=rate ratio. The Lancet 2019 393, 407-415DOI: (10.1016/S0140-6736(18)31942-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions