Volume 13, Issue 6, Pages R215-R216 (March 2003)

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Volume 13, Issue 6, Pages R215-R216 (March 2003) APC  Mariann Bienz  Current Biology  Volume 13, Issue 6, Pages R215-R216 (March 2003) DOI: 10.1016/S0960-9822(03)00152-0

Figure 1 Subcellular pools of APC. In epithelial cells (not stimulated by Wnt), APC moves between four different pools: from the nucleus and cytoplasm to the cell periphery where it associates with adherens junctions at the (apico)lateral plasma membrane, or with microtubule tips in the basal cell cortex. Its association with the Axin complex occurs in the cytoplasm, perhaps near the plasma membrane. APC appears to shuttle β-catenin between some of these pools. Current Biology 2003 13, R215-R216DOI: (10.1016/S0960-9822(03)00152-0)