Effects of neuropeptide treatment on APC stimulation of Ag-specific T cells. Effects of neuropeptide treatment on APC stimulation of Ag-specific T cells.

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Effects of neuropeptide treatment on APC stimulation of Ag-specific T cells. Effects of neuropeptide treatment on APC stimulation of Ag-specific T cells. The α-MSH/NPY–cotreated macrophages were fed opsonized OVA to process. OVA-specific T cells were added to the wells and assayed for proliferation. Presented are the relative levels of proliferation in comparison with the proliferation detected in the cultures of untreated OVA-presenting APC with OVA-specific T cells (OVA). Wells of no Ag contained only cultured APC with OVA-specific T cells. For Ag specificity, opsonized rat albumin was used instead of opsonized OVA (ratALB). The results presented are from nine independent cultures. This demonstrates that the treated APC are suppressed in their ability to stimulate Ag-specific T cell proliferation. The neuropeptide-treated APC were significantly suppressed (*p ≤ 0.001) in their ability to stimulate T cell proliferation. Isaac J. Benque et al. ImmunoHorizons 2018;2:314-323 Copyright © 2018 The Authors