Bell Ringer Objective: Explain that mutations occur during DNA replication or transcription and may be random or a result of environmental agents. Question:

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Bell Ringer Objective: Explain that mutations occur during DNA replication or transcription and may be random or a result of environmental agents. Question: POD page 35

changes in the sequence of DNA Mutations changes in the sequence of DNA

Locations: Mutation in Reproductive Cells 1. Sperm and/or eggs 2. Passed to the next generation

Location: Somatic (Body) Cell Mutation 1. Any cell other than egg or sperm cells 2. May/may not cause problems for the individual with the mutation 3. All cells that come from the mutated cell will have the mutation → may cause cancer 4. Will NOT be passed onto their offspring

Mutation Type: Nitrogen Base Point Mutation – change in one nitrogen base Original DNA – TCGATTTGA Changed DNA – TCGATATGA

Example of Point Mutations https://www.dnalc.org/resources/3d/17-sickle-cell.html

Mutation Type: Nitrogen Base Frameshift Mutation – single nitrogen base is added or deleted; results in a shift in the codon reading frame Original DNA – TCGATTTGA Addition – TCGAGTTTGA Deletion – TCGTTTGA

https://www.youtube.com/watch?v=RzEpkBU-ITA

Silent Mutations

Mutation Type: Chromosomal Mutations Original Chromosome – ABCDEFGHIJ (letter = gene) Deletion → ABCEFGHIJ **One or more genes is/are deleted

Chromosomal Deletion

Wolf-Hirschhorn syndrome

Mutation Type: Chromosomal Mutations Original Chromosome – ABCDEFGHIJ Inversion → ABCFEDGHIJ ***Set of genes are flipped/inverted

Chromosomal Inversion

Mutation Type: Chromosomal Mutations Original Chromosome – ABCDEFGHIJ Insertion → ABCDCDEFGHIJ ***One or more genes are re-inserted & appear more than one time ***Inserted genes may come from any chromosome

Chromosomal Insertion

Mutation Type: Chromosomal Mutations Original Chromosome – ABCDEFGHIJ Translocation → ABCDHIJ & ABCDEFGHIJEFG **One or more genes are moved from one chromosome to another chromosome; they exchange places

Chromosomal Translocation

Possible Causes of Mutations A. X-rays/exposure to radioactivity B. Exposure to UV (ultraviolet) light C. Exposure to harmful chemicals (mutagens) D. Unhealthy lifestyle → smoking, drugs, etc.

Mutation Mini “Lab”

Amoeba Sisters: on individual computers. (CC or headphones)