NMDA-Receptor Activation Induces Calpain-Mediated b-Catenin Cleavages for Triggering Gene Expression Kentaro Abe et al., Cell, (2007)

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NMDA-Receptor Activation Induces Calpain-Mediated b-Catenin Cleavages for Triggering Gene Expression Kentaro Abe et al., Cell, (2007)

NEURONAL ACTIVITY - REGULATION OF DENDRITIC BRANCH STABILITY BY NEURONAL ACTIVITY - ACTIVITY-DEPENDENT MODULATION OF LOCAL CYTOSKELETON AND ADHESION MOLECULES - REGULATION OF DENDRITIC DEVELOPMENT BY ACTIVITY DEPENDENT GENE EXPRESSION 뉴런은 일반 셀들과 다른 여러가지 특징들이 존재하는데, 그중에 대표적인 것이 뉴런날 엑티비티가 존재하 이런 뉴런의 Chen Y et al., J Neurobiol, (2005)

LTP ( long-terrm potentiation) Memory formation Chen Y et al., J Neurobiol, (2005)

NMDA (N-methyl-D-aspartate) receptor Cooke SF et al., Brain, (2006)

Calpain (calcium-dependent, non-lysosomal cysteine protease) Franco SJ et al., J Cell Sci (2005)

Calpain regulates cell migration Franco SJ et al., J Cell Sci (2005)

Motility-related calpain substrates of Calpain Franco SJ et al., J Cell Sci (2005)

Activity-Dependent Cleavages of b-Catenin by Calpain AVP : NMDA-R antagonist CNQX : AMPA-R antagonist MCPG : mGluR antagonist MDL28170 : calpain inhibitor

Activity-Dependent Cleavages of b-Catenin by Calpain MDL28170 : calpain inhibitor

Nuclear Translocation of Cleaved b-Catenin Fragments AVP : NMDA-R antagonist CNQX : AMPA-R antagonist MCPG : mGluR antagonist MDL28170 : calpain inhibitor

Activation of Tcf-Dependent Gene Transcription by the b-Catenin Fragments AVP : NMDA-R antagonist, MDL28170 : calpain inhibitor

Activation of Tcf-Dependent Gene Transcription by the b-Catenin Fragments MDL28170 : calpain inhibitor

Activation of Tcf-Dependent Gene Transcription by the b-Catenin Fragments

Calpain-Dependent b-Catenin Cleavage and Tcf Activation In Vivo