The Lancet Infectious Diseases

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The Lancet Infectious Diseases Active and passive case-finding in tuberculosis-affected households in Peru: a 10-year prospective cohort study Matthew J Saunders, MRCP, Marco A Tovar, MD, Dami Collier, MRCP, Matthew R Baldwin, MD, Rosario Montoya, Lic, Teresa R Valencia, Tec, Prof Robert H Gilman, MD, Prof Carlton A Evans, FRCP The Lancet Infectious Diseases DOI: 10.1016/S1473-3099(18)30753-9 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Study profile The Lancet Infectious Diseases DOI: (10.1016/S1473-3099(18)30753-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Cumulative risk and incidence of tuberculosis among contacts Error bars represent 95% CIs. The Lancet Infectious Diseases DOI: (10.1016/S1473-3099(18)30753-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 6-monthly rolling average number and cumulative proportion of contacts diagnosed with tuberculosis, by tuberculosis ascertainment strategy The Lancet Infectious Diseases DOI: (10.1016/S1473-3099(18)30753-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 4 Proportion of people with tuberculosis who were female, by tuberculosis ascertainment strategy Global and Latin American data were derived from the estimated tuberculosis incidence among people aged 15 years or older, reported by WHO.2 Peruvian data were derived from routinely available data.7 p values indicate two-sample proportion tests. Dotted line at 50% acts as a visual guide to show differences between groups. NA=not available. *Estimate. The Lancet Infectious Diseases DOI: (10.1016/S1473-3099(18)30753-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 5 Total symptom duration before diagnosis among contacts with tuberculosis with data available, by tuberculosis ascertainment strategy p value calculated with the Mann-Whitney U test and compares total symptom duration between the two tuberculosis ascertainment strategies. The Lancet Infectious Diseases DOI: (10.1016/S1473-3099(18)30753-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 6 Laboratory results among contacts diagnosed with tuberculosis, by tuberculosis ascertainment strategy p value indicates a two-sample proportion test comparing the proportion of contacts who are smear-negative between the two tuberculosis ascertainment strategies. The Lancet Infectious Diseases DOI: (10.1016/S1473-3099(18)30753-9) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions