ALK Rearrangement Detected in a Focus of Pulmonary Atypical Adenomatous Hyperplasia Filippo Lococo, MD, Alessandra Bisagni, MD, Maria Cecilia Mengoli,

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ALK Rearrangement Detected in a Focus of Pulmonary Atypical Adenomatous Hyperplasia Filippo Lococo, MD, Alessandra Bisagni, MD, Maria Cecilia Mengoli, MD, Alberto Cavazza, MD, Giulio Rossi, MD Journal of Thoracic Oncology Volume 12, Issue 5, Pages e37-e39 (May 2017) DOI: 10.1016/j.jtho.2016.12.007 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Computed tomography scan of the ground glass opacity with central solid area (A), corresponding to a minimally invasive adenocarcinoma with stromal invasion (B). A small (<5-mm) proliferation of alveolar lining cells (C) with minimal nuclear atypia and a hobnail appearance (D). Journal of Thoracic Oncology 2017 12, e37-e39DOI: (10.1016/j.jtho.2016.12.007) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Minimally invasive adenocarcinoma showing anaplastic lymphoma kinase (ALK) expression (immunohistochemistry, clone 5A4) (A) and anaplastic lymphoma receptor tyrosine kinase gene (ALK) rearrangement with typical ALK-positive pattern with fused (red circles) and split signals (red arrows) (fluorescence in situ hybridization) (B). Atypical adenomatous hyperplasia with ALK expression (C) and split signals (red arrows) corresponding to ALK rearrangement caused by intrachromosomal inversion (D). Journal of Thoracic Oncology 2017 12, e37-e39DOI: (10.1016/j.jtho.2016.12.007) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions