Primary Care Treatment of Hepatitis C

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Presentation transcript:

Primary Care Treatment of Hepatitis C The clinic champion in an urban academic family medicine practice STFM PRACTICE IMPROVEMENT CONFERENCE, DECEMBER 7, 2018 | PRESENTED BY: TIMOTHY L. HERRICK, M.D., M.S.

Disclosure I have nothing to disclose in terms of commercial interests or conflicts. I have no financial arrangements outside OHSU.

Objectives The participant will understand : what every PCP needs to do for their patients regarding Hep C Screening Management Three important elements for facilitating introduction of Hep C treatment into a FM practice Helpful relationship with Hep C experts including pharmacy The clinic champion The patient Navigator How residents can be involved in this process Co-scheduling Mentorship

Who is at High Risk The “birth cohort” [those born between 1945 and 1965] IVDU [60% of new Hep C used in last 6 months] Transfusion pre-1992 long-term hemodialysis, being born to an HCV-infected mother, incarceration, intranasal drug use, getting an unregulated tattoo, and other percutaneous exposures Country of origin [?]

Global Hep C situation

Tools for screening Health Maintenance tab Clinic registry EMR based Identifies all at risk Can break out by provider Can identify those needing further workup, RX

First step after screening Confirmation with PCR Should be reflex Viral load does not correlate with severity, histology Viral load may influence treatment plan Inform patient personally of positives

Caveats Known new diagnosis; could possibly clear so wait six months before treating. Predictors: Female sex Age < 40 Not co-infected or immunocompromised Presents with symptoms If Infection >2 years, spontaneous clearance very unlikely

Management of Hep C positive patients, 1. Screening for co-infection Presence of Hep B and HIV have treatment implications Need for hepatitis prevention by vaccination if non-immune: Hep A, Hep B, [also pneumococcal ppsv23] Counseling; ETOH!! Other pro-fibrotics? Acetaminophen; minimize transmission

Management of the Hep C patients, 2. [every pcp’s job!] Staging liver damage: Childs-Pugh staging; If cirrhosis: HCC screen, varices screen [thisrequirement remains after Rx] Treatment readiness abstinence [six months no needles, per insurance] ; adherence ; willingness to cooperate? Prior treatment? Tobacco;

Evaluation of Fibrosis Why: Fibrosis is the key to the pathophysiology of the insult to the liver, due to Chronic Hepatitis C, and the key to getting insurance to pay! How: liver biopsy; invasive, false negatives Fibroscan [or another image-based method] Fibrosure [or another proprietary blood-based fibrosis measure] When NOT TO?: when you have probable cirrhosis on an ultrasound. [why? Probable cirrhosis is enough to get treatment; a lower fibrosis number could knock you out!]

Treatment! More and more people are eligible Amenable to treatment in primary care. Those less suitable for primary care: Co-infections Significant liver disease [need for other agents, like ribavirin]

DAA mechanisms

Direct acting anti-virals

Helpful relationship with Hep C experts including pharmacy Important elements for facilitating introduction of Hep C treatment into an FM practice Helpful relationship with Hep C experts including pharmacy The clinic champion The patient Navigator

Helpful relationship with Hep C experts including pharmacy

Clinic champion A clinic of about 20000 will likely have fewer than 100 hep C patients It makes sense for one provider to take this on for the whole clinic When the clinic director asks you, what can you say?

Patient navigator Nursing background helpful Roughly 0.25 FTE for Hep C Handles patient scheduling of appointments and lab draws, patient communication, keeps “on” the patients

Resident Involvement Co-scheduling; in the same way that a faculty and resident are co-scheduled for a procedure, the resident and Hep C champion are co-scheduled, allowing for a shared clinic visit. Rationale and plan of the visit is shared with the resident, labs are reviewed and the resident does the documentation and orders, if needed. Outside residents schedule bloc time to spend in the clinic.

Results Since Jan 1, 2018, Fifteen patients started 8 patients have attained “SVR” 7 still being treated or awaiting 12 weeks after RX No failures, no dropouts

Future plans: Training a second Hep C provider for our clinic Building capacity to manage Hep C patients in all our clinics Expanding to offer Hep C care treatment in all clinics Opening up to offer DAA care to community patients outside our clinic.

Key Points What every PCP needs to do for their patients regarding Hep C screening Management Three important elements for facilitating introduction of Hep C treatment into a FM practice -helpful relationship with Hep C experts including pharmacy the clinic champion the patient navigator How residents can be involved in this process co-scheduling mentorship

Questions? herrickt@ohsu.edu