Volume 4, Issue 8, Pages (September 2018)

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Volume 4, Issue 8, Pages 837-840 (September 2018) 55-year-old man with ulcers in inguinal fold and intergluteal cleft found to have systemic Langerhans cell histiocytosis Euphemia W. Mu, MD, Nigar Anjuman Khurram, MD, Zhiheng Pei, MD, PhD, Hao Feng, MD, Nicholas Cassai, MS HTL(ASCP), Shane A. Meehan, MD, Jo-Ann Latkowski, MD JAAD Case Reports Volume 4, Issue 8, Pages 837-840 (September 2018) DOI: 10.1016/j.jdcr.2018.05.016 Copyright © 2018 Terms and Conditions

Fig 1 A and B, Well-demarcated inguinal and intergluteal ulcers found during physicial examination were nontender on palpation. JAAD Case Reports 2018 4, 837-840DOI: (10.1016/j.jdcr.2018.05.016) Copyright © 2018 Terms and Conditions

Fig 2 Colon and skin histopathology of patient with Langerhans cell histiocytosis. A, Polypoid colonic lesion shows a dense proliferation of histiocytes in the submucosa with eosinophilic abscesses in addition to neutrophilic and lymphocytic infiltrates. B, Oval histiocytes approximately 15 μm characterized by folded, indented or lobulated nuclei with fine chromatin, inconspicuous nucleoli, and thin nuclear membranes. The cytoplasms are moderately abundant and slightly eosinophilic. C, Langerhans cell histiocytosis involvement at colon. D, Skin biopsy reveals similar infiltrate to that of the colon specimen. E, Histiocytes with large, pale, folded or lobulated (often reniform), vesicular nuclei and abundant, slightly eosinophilic or amphophilic cytoplasms. F, Histiocytic infiltrate. (A, B, D, and E; Hematoxylin-eosin stain; C and F; CD1a stain; original magnification: A, C, D, and F, X2; B and E, X20.) JAAD Case Reports 2018 4, 837-840DOI: (10.1016/j.jdcr.2018.05.016) Copyright © 2018 Terms and Conditions

Fig 3 Electron microscopy image of cytoplasm of Langerhans cell shows characteristic Birbeck granules. JAAD Case Reports 2018 4, 837-840DOI: (10.1016/j.jdcr.2018.05.016) Copyright © 2018 Terms and Conditions