R.N. Upton, A.M. Martinez, C. Grant British Journal of Anaesthesia

Slides:

Advertisements

Similar presentations

B.D. Woods, R.N. Sladen British Journal of Anaesthesia

Advertisements

T. Tedore British Journal of Anaesthesia

Impact of xenon anaesthesia in isolated cardiopulmonary bypass on very early leucocyte and platelet activation and clearance: a randomized, controlled.

Functional walking capacity as an outcome measure of laparoscopic prostatectomy: the effect of lidocaine infusion S. Lauwick, D.J. Kim, G. Mistraletti,

Effects of maintaining a remifentanil infusion on the recovery profiles during emergence from anaesthesia and tracheal extubation J.-S. Nho, S.-Y. Lee,

Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation† G.A. Hans, S.M. Lauwick, A.

T. N. Weingarten, F. X. Whalen, D. O. Warner, O. Gajic, G. J

Critical involvement of the thalamus and precuneus during restoration of consciousness with physostigmine in humans during propofol anaesthesia: a positron.

Parkinson's disease and anaesthesia

The two-compartment recirculatory pharmacokinetic model'an introduction to recirculatory pharmacokinetic concepts Upton R.N. British Journal of Anaesthesia

Orthostatic function and the cardiovascular response to early mobilization after breast cancer surgery R.G. Müller, M. Bundgaard-Nielsen, H. Kehlet

Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass E Takizawa, H Hiraoka, D Takizawa,

A.F. Kopman, C.A. Lien, M Naguib British Journal of Anaesthesia

Prediction of arterial oxygen partial pressure after changes in FiO2: validation and clinical application of a novel formula† H.M. Al-Otaibi, J.G. Hardman

M. Naguib, D. L. Hammond, P. G. Schmid III, M. T. Baker, J. Cutkomp, L

M. Carron, U. Freo, C. Ori British Journal of Anaesthesia

M. Boutonnet, V. Faitot, A. Katz, L. Salomon, H. Keita

Ventilatory ratio: a simple bedside measure of ventilation

J.-Y. Hwang, H.-S. Na, Y.-T. Jeon, Y.-J. Ro, C.-S. Kim, S.-H. Do

Dose adjustment of anaesthetics in the morbidly obese

Upton R.N. , Grant C. , Martinez A.M. , Ludbrook G.L.

B.M.Q. Weaver, G.E. Staddon, W.W. Mapleson

O. Thom, D. M. Taylor, R. E. Wolfe, J. Cade, P. Myles, H. Krum, R

Chronic opioid therapy for non-cancer pain

Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats A Dahan, A Yassen, H Bijl, R Romberg, E Sarton, L.

Development of atelectasis and arterial to end-tidal Pco2-difference in a porcine model of pneumoperitoneum C.M. Strang, T. Hachenberg, F. Fredén, G.

H. Yamauchi, S. Ito, H. Sasano, T. Azami, J. Fisher, K. Sobue

Glycopyrrolate during sevoflurane–remifentanil-based anaesthesia for cardiac catheterization of children with congenital heart disease K. Reyntjens,

Efficacy of intravenous magnesium in neuropathic pain

Detection of awareness in surgical patients with EEG-based indices—bispectral index and patient state index†‡ G. Schneider, A.W. Gelb, B. Schmeller,

D.H.J. Davis, M. Oliver, A.J. Byrne British Journal of Anaesthesia

Development of acute tolerance to the EEG effect of propofol in rats†

R.N. Upton, G.L. Ludbrook, A.M. Martinez, C Grant, R.W. Milne

J.E. Hall, T.D. Uhrich, T.J. Ebert British Journal of Anaesthesia

B. McNamara, J. Ray, D. Menon, S. Boniface

D. Jee, D. Lee, S. Yun, C. Lee British Journal of Anaesthesia

Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious.

Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia C. Jeleazcov, M. Lavielle, J. Schüttler,

O. Pruszkowski, N. Dalibon, M. Moutafis, E. Jugan, J. D. Law-Koune, P

S Singh, J.E. Smith British Journal of Anaesthesia

Physiological effects of hyperchloraemia and acidosis

Suppressive effect of nitrous oxide on motor evoked potentials can be reversed by train stimulation in rabbits under ketamine/fentanyl anaesthesia, but.

Wash-in kinetics for sevoflurane using a disposable delivery system (AnaConDa®) in cardiac surgery patients L.W. Sturesson, A. Johansson, M. Bodelsson,

The output of two sevoflurane vaporizers in the presence of helium

Y.A. Zausig, H. Künzig, G. Roth, B.M. Graf

Comparison of 1% and 2% lidocaine epidural anaesthesia combined with sevoflurane general anaesthesia utilizing a constant bispectral index A Shono, S.

H.M. Soliman, C. Mélot, J.-L. Vincent British Journal of Anaesthesia

M. Dosani, J. Lim, P. Yang, C. Brouse, J. Daniels, G. Dumont, J. M

M Kodaka, Y Okamoto, F Handa, J Kawasaki, H Miyao

A unique effect of propofol on the jaw opening reflex

C. Menigaux, B. Guignard, F. Adam, D.I. Sessler, V. Joly, M. Chauvin

Efficacy of butylscopolamine for the treatment of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study

The effect of ephedrine on intubating conditions and haemodynamics during rapid tracheal intubation using propofol and rocuronium M.D. Gopalakrishna,

Effect of short-term exercise training on aerobic fitness in patients with abdominal aortic aneurysms: a pilot study E. Kothmann, A.M. Batterham, S.J.

J.E. Spiegel, A. Vasudevan, Y. Li, P.E. Hess

P Schramm, K Engelhard, A Scherhag, F Schier, C Werner

Effects of remifentanil on cardiovascular and bispectral index responses to endotracheal intubation in severe pre-eclamptic patients undergoing Caesarean.

Diffusion of nitrous oxide into the pleural cavity†

Assessment of pulse transit time to indicate cardiovascular changes during obstetric spinal anaesthesia† G Sharwood-Smith, J Bruce, G Drummond British.

Reduction of vasopressor requirement by hydrocortisone administration in a patient with cerebral vasospasm J.A. Alhashemi British Journal of Anaesthesia

P. Brassard, T. Seifert, N.H. Secher British Journal of Anaesthesia

Haemodynamic effects of oxytocin given as i. v

Small dose of clonidine mixed with low-dose ropivacaine and fentanyl for epidural analgesia after total knee arthroplasty† Förster J.G. , Rosenberg P.H.

Early stages of propofol infusion syndrome in paediatric cardiac surgery: two cases in adolescent girls N. Laquay, P. Pouard, M.A. Silicani, L. Vaccaroni,

Comparison of different methods of ventilation via cannula cricothyroidotomy in a trachea–lung model† N.J. Flint, W.C. Russell, J.P. Thompson British.

Rocuronium dose-dependently suppresses the spectral entropy response to tracheal intubation during propofol anaesthesia M. Kawaguchi, I. Takamatsu, T.

Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate† J.-H. Ryu, I.-S. Sohn, S.-H. Do British Journal.

Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery M. Grossherr, A. Hengstenberg,

Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing.

R. Parke, S. McGuinness, R. Dixon, A. Jull

Presentation transcript:

Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep R.N. Upton, A.M. Martinez, C. Grant British Journal of Anaesthesia Volume 103, Issue 6, Pages 848-857 (December 2009) DOI: 10.1093/bja/aep269 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 The effect of CNS 7056 on EEG α power. A loess smoothing function was applied to the pooled EEG data for each dose group. The drug infusions were from 0 to 2 min. Note that the smoothing function is responsible for the slight increase in α power before the start of drug administration at time zero. British Journal of Anaesthesia 2009 103, 848-857DOI: (10.1093/bja/aep269) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 The effect of midazolam on EEG α power. A loess smoothing function was applied to the pooled EEG data for each dose group. The drug infusions were from 0 to 2 min. British Journal of Anaesthesia 2009 103, 848-857DOI: (10.1093/bja/aep269) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 The effect of propofol on EEG α power. A loess smoothing function was applied to the pooled EEG data for each dose group. The drug infusions were from 0 to 2 min. British Journal of Anaesthesia 2009 103, 848-857DOI: (10.1093/bja/aep269) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 4 Change in arterial oxygen tension vs depth of anaesthesia. This graph shows the relationship between the maximum change in the α power of the EEG (reflecting the depth of anaesthesia) and the change in arterial oxygen tension (Pao2) at 2 min, reflecting the magnitude of respiratory depression. Each symbol is the mean of one dose group for the drugs shown. The R2 value of the line of best fit was 0.78, the slope was [mean (se)] −2.37 (0.45) (P<0.01). The non-zero slope of the line supports the general hypothesis that (regardless of the drug) the greater the anaesthesia, the greater the respiratory depression. British Journal of Anaesthesia 2009 103, 848-857DOI: (10.1093/bja/aep269) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 5 Change in MAP vs depth of anaesthesia. This graph shows the relationship between the maximum change in the α power of the EEG (reflecting the depth of anaesthesia) and the change in MAP at 2 min, reflecting the magnitude of cardiovascular depression. Each symbol is the mean of one dose group for the drugs shown. The R2 value of the line of best fit was 0.39, the slope was [mean (se)] −0.61 (0.27) (P=0.05). Although not statistically significant, trend in the data supports the general hypothesis that (regardless of the drug) the greater the anaesthesia, the greater the cardiovascular depression. British Journal of Anaesthesia 2009 103, 848-857DOI: (10.1093/bja/aep269) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 6 Change in heart rate vs depth of anaesthesia. This graph shows the relationship between the maximum change in the α power of the EEG (reflecting the depth of anaesthesia) and the maximum change in heart rate, reflecting the magnitude of cardiovascular depression. Each symbol is the mean of one dose group for the drugs shown. The R2 value of the line of best fit was 0.75, the slope was [mean (se)] 3.37 (0.68) (P<0.01). The non-zero slope of the line supports the general hypothesis that (regardless of the drug) the greater the anaesthesia, the greater the cardiovascular depression. British Journal of Anaesthesia 2009 103, 848-857DOI: (10.1093/bja/aep269) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions