Isolated lung perfusion with platinum in the treatment of pulmonary metastases from soft tissue sarcomas G.B. Ratto, MDa, S. Toma, MDb, D. Civalleri,

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Presentation transcript:

Isolated lung perfusion with platinum in the treatment of pulmonary metastases from soft tissue sarcomas G.B. Ratto, MDa, S. Toma, MDb, D. Civalleri, MDc, G.C. Passerone, MDc, M. Esposito, PhDb, D. Zaccheo, MDe, M. Canepa, MDd, P. Romano, PhDe, R. Palumbo, MDb, F. De Cian, MDc, F. Scarano, MDc, M. Vannozzi, PhDb, E. Spessa, MDa, G. Fantino, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 3, Pages 614-622 (September 1996) DOI: 10.1016/S0022-5223(96)70043-0 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Diagram of perfusion circuit. OX, Oxygenator. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 614-622DOI: (10.1016/S0022-5223(96)70043-0) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Chest roentgenogram, 48 hours after isolated lung perfusion, showing conspicuous interstitial and alveolar edema in treated organ. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 614-622DOI: (10.1016/S0022-5223(96)70043-0) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Semilogarithmic plot of total and filterable platinum (PT) concentrations versus time, in systemic and pulmonary plasma, during isolated lung perfusion (values represent means plus or minus standard deviation). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 614-622DOI: (10.1016/S0022-5223(96)70043-0) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Platinum (PT) concentrations in normal lung and neoplastic tissue during isolated lung perfusion (values represent means plus or minus standard deviation). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 614-622DOI: (10.1016/S0022-5223(96)70043-0) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Changes of pulmonary function parameters before and after isolated lung perfusion. DLCO, diffusing capacity of carbon monoxide; Po 2 , oxygen tension; Pco 2 , carbon dioxide tension. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 614-622DOI: (10.1016/S0022-5223(96)70043-0) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 6 TEM and SEM appearances of normal pulmonary parenchyma after 1 hour of isolated lung perfusion. Top left, Intact interalveolar septum with minimal pneumocyte hypertrophy (TEM, original magnification ×4400). Top right, Detail of interalveolar septum showing pneumocyte with mild ectasia of smooth endoplasmic reticulum (TEM, original magnification ×3000). Bottom left, Undamaged capillary wall (TEM, original magnification ×4400). Bottom right, Complete and uninjured alveolar epithelial lining (SEM, original magnification ×390). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 614-622DOI: (10.1016/S0022-5223(96)70043-0) Copyright © 1996 Mosby, Inc. Terms and Conditions