How Long Should Small Lung Lesions of Ground-Glass Opacity be Followed? Yoshihisa Kobayashi, MD, Takayuki Fukui, MD, Simon Ito, MD, Noriyasu Usami, MD,

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How Long Should Small Lung Lesions of Ground-Glass Opacity be Followed? Yoshihisa Kobayashi, MD, Takayuki Fukui, MD, Simon Ito, MD, Noriyasu Usami, MD, Shunzo Hatooka, MD, Yasushi Yatabe, MD, Tetsuya Mitsudomi Journal of Thoracic Oncology Volume 8, Issue 3, Pages 309-314 (March 2013) DOI: 10.1097/JTO.0b013e31827e2435 Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Computed tomography images of two representative pulmonary nodules with GGO. A, A part solid (1%–25 %) GGO lesion became larger and increased the solid component (26%–50 %) after 3.3 years. B, However, a pure GGO lesion had persisted without changing in size for 6.3 years. GCO, ground-glass opacity. Journal of Thoracic Oncology 2013 8, 309-314DOI: (10.1097/JTO.0b013e31827e2435) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 The changes in size of the 108 evaluated lesions, (A) from the time of the first presentation to the last computed tomography examination. B, Some of the 69 lesions that were 1 cm or less in size became larger, (C), some of the 82 pure GGO lesions also grew in size during the observation period. GCO, ground-glass opacity. Journal of Thoracic Oncology 2013 8, 309-314DOI: (10.1097/JTO.0b013e31827e2435) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 The changes in size of all 29 lesions that grew. The changes in size between CT examinations were measured to analyze each lesion's tendency to grow. The first changes in size are shown with highly colored lines and subsequent changes are shown with light-colored lines. All 29 lesions began to grow within the first 3 years of observation. CT, computed tomography. Journal of Thoracic Oncology 2013 8, 309-314DOI: (10.1097/JTO.0b013e31827e2435) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions