Volume 60, Issue 5, Pages 1885-1892 (November 2001) Glomerular protein sieving and implications for renal failure in Fanconi syndrome  Anthony G.W. Norden, Marta Lapsley, Philip J. Lee, Charles D. Pusey, Steven J. Scheinman, Frederick W.K. Tam, Rajesh V. Thakker, Robert J. Unwin, Oliver Wrong  Kidney International  Volume 60, Issue 5, Pages 1885-1892 (November 2001) DOI: 10.1046/j.1523-1755.2001.00016.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Estimated glomerular sieving coefficients for 12 plasma proteins versus molecular weight. Data are from Table 1; mean (± SEM) of five determinations based on results from each of five patients with Dent's disease are shown. See Molecular size, charge and glomerular sieving for discussion of the anomalous behavior of α1-acid glycoprotein (α1AG) and β2-glycoprotein-I (β2GI). Abbreviations are: RBP, retinol-binding protein; α2m, α2-microglobulin; TSH, thyroid-stimulating hormone; ZAG, zinc-α2-globulin; DBP, vitamin D-binding protein; TTR, transthyretin; ALB, albumin; TRF, transferrin; IgG, immunoglobulin G. Kidney International 2001 60, 1885-1892DOI: (10.1046/j.1523-1755.2001.00016.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Hormone and chemokine excretion in urine of patients with Dent's disease (•); Lowe's syndrome (▴); autosomal-dominant idiopathic Fanconi syndrome (ADIF) (▾), and normal individuals (□). Data are from Table 2. Excretion, in the following units, is expressed per mmol creatinine: parathyroid hormone, ng; insulin, pmol; IGF-1, nmol; prolactin, mIU; growth hormone, mIU; luteinizing hormone, mIU and MCP-1, ng. Kidney International 2001 60, 1885-1892DOI: (10.1046/j.1523-1755.2001.00016.x) Copyright © 2001 International Society of Nephrology Terms and Conditions