Hippo Pathway Key to Ploidy Checkpoint

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Hippo Pathway Key to Ploidy Checkpoint Bin Zhao, Kun-Liang Guan Cell Volume 158, Issue 4, Pages 695-696 (August 2014) DOI: 10.1016/j.cell.2014.07.041 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 LATS2 in Tetraploidy-Induced Cell-Cycle Arrest Most tetraploid cells have extra centrosomes and abnormal cytoskeleton, which lead to genomic instability. On the other hand, tetraploid cells are prevented from erotic cell divisions by cell-cycle arrest, largely due to p53 activation, although activation of growth factor signaling can bypass cell-cycle arrest in a p53-independent manner. A model is proposed that extra centrosomes initiate G1 arrest via a Rac-Rho-LATS2-YAP pathway. Activation of certain GPCR signaling inhibits LATS2 and enhances evasion of cell-cycle arrest. LATS2 also promotes proper cytokinesis and inhibits centrosome overduplication, thus inhibiting tetraploidy. The Hippo pathway is highlighted in blue. Cell 2014 158, 695-696DOI: (10.1016/j.cell.2014.07.041) Copyright © 2014 Elsevier Inc. Terms and Conditions