Volume 63, Issue 4, Pages 1499-1507 (April 2003) The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: The RENAAL Study  William F. Keane, Barry M. Brenner, Dick de Zeeuw, Jean-Pierre Grunfeld, Janet McGill, William E. Mitch, Artur B. Ribeiro, Shahnaz Shahinfar, Roger L. Simpson, Steven M. Snapinn, Robert Toto, RENAAL Study Investigators  Kidney International  Volume 63, Issue 4, Pages 1499-1507 (April 2003) DOI: 10.1046/j.1523-1755.2003.00885.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Kaplan-Meier estimates of event rate for doubling serum creatinine (DsCr) or end-stage renal disease (ESRD) stratified by quartiles. (A) Baseline urine albumin creatinine (Alb:Cr) ratio. The hazard ratio (HR) for each quartile was calculated and compared with that of the patients with the lowest values, who are in the reference quartile with a HR of 1.0. (—), Reference value Alb:Cr ratio>2.6 or>4.4 g protein/24 hours; (—), Alb:Cr ratio of 1.2 to 2.6 or 2.4 to 4.4 g protein/24 hours; (—), Alb:Cr ratio of 0.56 to 1.1 or 1.3 to 2.3 g protein/24 hours; (···), Alb:Cr ratio of <0.56 or <1.3 g protein/24 hours. (B) Baseline serum creatinine. The HR for each quartile was calculated and compared with that of the patients with the lowest values, who are in the reference quartile with a HR of 1.0. (—), Reference value of serum creatinine>2.1 mg/dL; (—), serum creatinine 1.8 to 2.1 mg/dL; (—), serum creatinine 1.5 to 1.7 mg/dL; (···), serum creatinine <1.5 mg/dL). (C) Baseline serum albumin. The HR for each quartile was calculated and compared with that of the patients with the highest values, who are in the reference quartile with a HR of 1.0. (···), Reference value of serum albumin <3.6 g/dL; (—), serum albumin 3.6 to 3.8 g/dL; (—), serum albumin 3.9 to 4.0 g/dL; (—) serum albumin>4.0 g/dL. (D) Baseline hemoglobin. The HR for each quartile was calculated and compared with that of the patients with the highest values, who are in the reference quartile with a HR of 1.0. (···), Reference value of hemoglobin <11.2 g/dL; (—), hemoglobin 12.4 to 11.2 g/dL; (—), hemoglobin 13.8 to 12.5 g/dL; (—), hemoglobin>13.8 g/dL. Kidney International 2003 63, 1499-1507DOI: (10.1046/j.1523-1755.2003.00885.x) Copyright © 2003 International Society of Nephrology Terms and Conditions