Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass: A randomized controlled trial Marcos A. Pavione, MD, Fabio Carmona,

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Presentation transcript:

Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass: A randomized controlled trial Marcos A. Pavione, MD, Fabio Carmona, MD, Margaret de Castro, MD, Ana P.C.P. Carlotti, MD The Journal of Thoracic and Cardiovascular Surgery Volume 144, Issue 1, Pages 178-183.e1 (July 2012) DOI: 10.1016/j.jtcvs.2011.12.029 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Postoperative cTnI plasma levels in patients from RIPC (hashed boxes) and control (white boxes) groups. Central lines are medians, boxes are interquartile ranges, and brackets are total range. CPB, Cardiopulmonary bypass; cTnI, cardiac troponin I. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 178-183.e1DOI: (10.1016/j.jtcvs.2011.12.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Left: Postoperative NT-proBNP plasma levels in patients from RIPC (hashed boxes) and control (white boxes) groups. Central lines are medians, boxes are interquartile ranges, and brackets are total range. Right: Areas under the curve of postoperative plasma NT-proBNP mean values in patients from RIPC (dark gray) and control (light gray) groups. ∗P = .03. CPB, Cardiopulmonary bypass; NT-proBNP, N-terminal pro-B-type natriuretic peptide; RIPC, remote ischemic preconditioning. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 178-183.e1DOI: (10.1016/j.jtcvs.2011.12.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Postoperative IL-8 (left) and IL-10 (right) plasma levels in patients from RIPC (hashed boxes) and control (white boxes) groups. Central lines are medians, boxes are interquartile ranges, and brackets are total range. CPB, Cardiopulmonary bypass; IL, interleukin. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 178-183.e1DOI: (10.1016/j.jtcvs.2011.12.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Flow diagram of the study. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 178-183.e1DOI: (10.1016/j.jtcvs.2011.12.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Postoperative IκBα mRNA relative quantification in patients from RIPC (hashed boxes) and control (white boxes) groups. Central lines are medians, boxes are interquartile ranges, and brackets are total range. CPB, Cardiopulmonary bypass; IκBα, I kappa B alpha. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 178-183.e1DOI: (10.1016/j.jtcvs.2011.12.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Postoperative IκBα mRNA relative quantification and total NF-κB protein relative quantification of 3 randomly selected patients. IκBα, I kappa B alpha; NF-κB, nuclear factor kappa B. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 178-183.e1DOI: (10.1016/j.jtcvs.2011.12.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions